Literature DB >> 19275525

Antimitotic chalcones and related compounds as inhibitors of tubulin assembly.

Sylvie Ducki1.   

Abstract

The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.

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Year:  2009        PMID： 19275525     DOI： 10.2174/1871520610909030336

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  21 in total

1.  Synthesis and biological evaluation of structurally diverse α-conformationally restricted chalcones and related analogues.

Authors:  Casey J Maguire; Graham J Carlson; Jacob W Ford; Tracy E Strecker; Ernest Hamel; Mary Lynn Trawick; Kevin G Pinney
Journal:  Medchemcomm       Date:  2019-06-04       Impact factor: 3.597

2.  Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2010-06-01       Impact factor: 3.641

3.  Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Dora Carrion; Carlota Lopez Cara; Olga Cruz-Lopez; Manlio Tolomeo; Stefania Grimaudo; Antonietta Di Cristina; Maria Rosaria Pipitone; Jan Balzarini; Nicola Zonta; Andrea Brancale; Ernest Hamel
Journal:  Bioorg Med Chem       Date:  2009-08-20       Impact factor: 3.641

4.  Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death.

Authors:  Michael W Robinson; Jean H Overmeyer; Ashley M Young; Paul W Erhardt; William A Maltese
Journal:  J Med Chem       Date:  2012-02-28       Impact factor: 7.446

5.  1,3-diaryl-2-propenones and 2-benzylidene-1,3-indandiones: a quest for compounds displaying greater toxicity to neoplasms than normal cells.

Authors:  Hari N Pati; Umashankar Das; Hiroshi Sakagami; Masame Kawase; Qing Chu; Qintao Wang; James P Stables; Jonathan R Dimmock
Journal:  Arch Pharm (Weinheim)       Date:  2010-09       Impact factor: 3.751

Review 6.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

7.  Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.

Authors:  Lívia B Salum; Wanessa F Altei; Louise D Chiaradia; Marlon N S Cordeiro; Rafael R Canevarolo; Carolina P S Melo; Evelyn Winter; Bruno Mattei; Hikmat N Daghestani; Maria Cláudia Santos-Silva; Tânia B Creczynski-Pasa; Rosendo A Yunes; José A Yunes; Adriano D Andricopulo; Billy W Day; Ricardo J Nunes; Andreas Vogt
Journal:  Eur J Med Chem       Date:  2013-03-06       Impact factor: 6.514

8.  Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells.

Authors:  David Drutovic; Martina Chripkova; Martina Pilatova; Peter Kruzliak; Pal Perjesi; Marek Sarissky; Monica Lupi; Giovanna Damia; Massimo Broggini; Jan Mojzis
Journal:  Tumour Biol       Date:  2014-07-10

9.  A Novel Fluorescent Probe for Selective Detection of Hydrazine and Its Application in Imaging.

Authors:  Ruo-Jun Man; Meng-Ke Wu; Bing Yang; Yu-Shun Yang
Journal:  Biosensors (Basel)       Date:  2021-04-22

10.  Microtubule S-glutathionylation as a potential approach for antimitotic agents.

Authors:  Wei Chen; Teresa Seefeldt; Alan Young; Xiaoying Zhang; Yong Zhao; John Ruffolo; Radhey S Kaushik; Xiangming Guan
Journal:  BMC Cancer       Date:  2012-06-15       Impact factor: 4.430
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