Literature DB >> 192752

Identification of a receptor for somatomedin-like polypeptides in human fibroblasts.

M M Rechler, S P Nissley, J M Podskalny, A C Moses, L Fryklund.   

Abstract

We have demonstrated a specific receptor for somatomedin-like growth polypeptides in human fibroblasts in culture using the closely related polypeptide, multiplication stimulating activity (MSA), as the radioligand. Polypeptides purified from human plasma, somatomedin A and acid soluble nonsuppressible insulin-like activity (NSILA-s), competed potently for 125I-MSA binding, as did unlabeled MSA. Although insulin and proinsulin also strongly inhibited MSA binding, the properties of the growth peptide receptor differed from those of the human fibroblasts insulin receptor. Somatomedin A, NSILA-s, MSA, insulin and proinsulin all stimulated the incorporation of [3H]thymidine into DNA in human fibroblasts. We propose that these polypeptides induce DNA synthesis through their interaction with the growth peptide receptor.

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Year:  1977        PMID： 192752     DOI： 10.1210/jcem-44-5-820

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  14 in total

1.  Effect of multiplication-stimulating activity on DNA and protein synthesis in cultured fetal rat calvaria.

Authors:  E Canalis; L G Raisz
Journal:  Calcif Tissue Int       Date:  1979-11       Impact factor: 4.333

2.  Enhancement of human granulopoiesis in vitro by biosynthetic insulin-like growth factor I/somatomedin C and human growth hormone.

Authors:  S Merchav; I Tatarsky; Z Hochberg
Journal:  J Clin Invest       Date:  1988-03       Impact factor: 14.808

3.  Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.

Authors:  C H Heldin; B Westermark; A Wasteson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

4.  Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

Authors:  J S Flier; P Usher; A C Moses
Journal:  Proc Natl Acad Sci U S A       Date:  1986-02       Impact factor: 11.205

5.  Structural and functional characterization of the human T lymphocyte receptor for insulin-like growth factor I in vitro.

Authors:  V F Tapson; M Boni-Schnetzler; P F Pilch; D M Center; J S Berman
Journal:  J Clin Invest       Date:  1988-09       Impact factor: 14.808

6.  Insulin-like growth factor characteristics of an acidic non-suppressible insulin-like activity.

Authors:  A C Herington; A D Kuffer
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

7.  Identification and characterization of insulin receptors on foetal-mouse brain-cortical cells.

Authors:  C F Van Schravendijk; E L Hooghe-Peters; P De Meyts; D G Pipeleers
Journal:  Biochem J       Date:  1984-05-15       Impact factor: 3.857

8.  Sequential addition of platelet factor and plasma to BALB/c 3T3 fibroblast cultures stimulates somatomedin-C binding early in cell cycle.

Authors:  D R Clemmons; J J Van Wyk; W J Pledger
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

9.  Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media.

Authors:  M A De Vroede; L Y Tseng; P G Katsoyannis; S P Nissley; M M Rechler
Journal:  J Clin Invest       Date:  1986-02       Impact factor: 14.808

10.  Type II insulin-like growth factor receptor is present in rat serum.

Authors:  W Kiess; L A Greenstein; R M White; L Lee; M M Rechler; S P Nissley
Journal:  Proc Natl Acad Sci U S A       Date:  1987-11       Impact factor: 11.205
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