Literature DB >> 19273797

Longitudinal incidence of adverse outcomes of age-related macular degeneration.

Ashley Wysong1, Paul P Lee, Frank A Sloan.   

Abstract

OBJECTIVE: To describe the visual, functional, and general health complication rates associated with age-related macular degeneration (AMD) in a nationally representative longitudinal sample of elderly persons.
METHODS: This is a longitudinal retrospective cohort study (January 1, 1994-December 31, 2004) that used Medicare claims data. We identified beneficiaries aged 68 years and older who had newly diagnosed AMD in 1994 (n = 32,702) and age-, sex-, and race-matched controls who had routine eye surveillance and no diagnosis of AMD throughout the observational period (n = 32,702). Main outcome measures included cumulative incidence of vision loss, blindness, hip fracture, depression, and nursing home placement and prevalence of 16 general health conditions.
RESULTS: Elderly individuals with newly diagnosed AMD had higher rates of blindness, vision loss, depression, hip fracture, and residence in a nursing home than those without AMD during a 10-year follow-up period. Individuals with AMD also had a higher prevalence of 11 of 16 general health conditions compared with controls.
CONCLUSIONS: Individuals aged 68 years and older with AMD had higher rates of visual and functional impairments and had more illness than controls. Our findings demonstrate the substantial resource commitment of caring for the multifaceted health issues of persons diagnosed with AMD.

Entities:  

Mesh:

Year:  2009        PMID: 19273797      PMCID: PMC3621973          DOI: 10.1001/archophthalmol.2008.613

Source DB:  PubMed          Journal:  Arch Ophthalmol        ISSN: 0003-9950


  39 in total

1.  Body mass index and the incidence of visually significant age-related maculopathy in men.

Authors:  D A Schaumberg; W G Christen; S E Hankinson; R J Glynn
Journal:  Arch Ophthalmol       Date:  2001-09

2.  Prevalence, expenditures, and complications of multiple chronic conditions in the elderly.

Authors:  Jennifer L Wolff; Barbara Starfield; Gerard Anderson
Journal:  Arch Intern Med       Date:  2002-11-11

3.  Associations of visual function with physical outcomes and limitations 5 years later in an older population: the Beaver Dam eye study.

Authors:  Barbara E K Klein; Scot E Moss; Ronald Klein; Kristine E Lee; Karen J Cruickshanks
Journal:  Ophthalmology       Date:  2003-04       Impact factor: 12.079

4.  Prevalence and causes of visual field loss in the elderly and associations with impairment in daily functioning: the Rotterdam Study.

Authors:  R S Ramrattan; R C Wolfs; S Panda-Jonas; J B Jonas; D Bakker; H A Pols; A Hofman; P T de Jong
Journal:  Arch Ophthalmol       Date:  2001-12

5.  Activity loss and depression in age-related macular degeneration.

Authors:  Barry W Rovner; Robin J Casten
Journal:  Am J Geriatr Psychiatry       Date:  2002 May-Jun       Impact factor: 4.105

6.  Causes of blindness and visual impairment in a population of older Americans: The Salisbury Eye Evaluation Study.

Authors:  B Muñoz; S K West; G S Rubin; O D Schein; H A Quigley; S B Bressler; K Bandeen-Roche
Journal:  Arch Ophthalmol       Date:  2000-06

7.  Visual impairment and nursing home placement in older Australians: the Blue Mountains Eye Study.

Authors:  Jie Jin Wang; Paul Mitchell; Robert G Cumming; Wayne Smith
Journal:  Ophthalmic Epidemiol       Date:  2003-02       Impact factor: 1.648

8.  Incidence of exudative age-related macular degeneration among elderly Americans.

Authors:  Jonathan C Javitt; Zhiyuan Zhou; Maureen G Maguire; Stuart L Fine; Richard J Willke
Journal:  Ophthalmology       Date:  2003-08       Impact factor: 12.079

9.  Effect of depression on vision function in age-related macular degeneration.

Authors:  Barry W Rovner; Robin J Casten; William S Tasman
Journal:  Arch Ophthalmol       Date:  2002-08

10.  Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio.

Authors:  Johanna M Seddon; Jennifer Cote; Nancy Davis; Bernard Rosner
Journal:  Arch Ophthalmol       Date:  2003-06
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  18 in total

Review 1.  How does the macula protect itself from oxidative stress?

Authors:  James T Handa
Journal:  Mol Aspects Med       Date:  2012-04-05

2.  Beyond AREDS: is there a place for antioxidant therapy in the prevention/treatment of eye disease?

Authors:  Renu A Kowluru; Qing Zhong
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-11-07       Impact factor: 4.799

3.  Health services research and how it can inform the current state of ophthalmology.

Authors:  Kelly W Muir; Hayden B Bosworth; Paul P Lee
Journal:  Am J Ophthalmol       Date:  2010-12       Impact factor: 5.258

4.  The effects of technological advances on outcomes for elderly persons with exudative age-related macular degeneration.

Authors:  Frank A Sloan; Brian W Hanrahan
Journal:  JAMA Ophthalmol       Date:  2014-04-01       Impact factor: 7.389

Review 5.  The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.

Authors:  Sayantan Datta; Marisol Cano; Katayoon Ebrahimi; Lei Wang; James T Handa
Journal:  Prog Retin Eye Res       Date:  2017-03-20       Impact factor: 21.198

6.  Longitudinal relationships among visual acuity, daily functional status, and mortality: the Salisbury Eye Evaluation Study.

Authors:  Sharon L Christ; D Diane Zheng; Bonnielin K Swenor; Byron L Lam; Sheila K West; Stacey L Tannenbaum; Beatriz E Muñoz; David J Lee
Journal:  JAMA Ophthalmol       Date:  2014-12       Impact factor: 7.389

7.  Ratio of urine albumin to creatinine attenuates the association of dementia with hip fracture risk.

Authors:  Petra Bůžková; Joshua I Barzilay; Howard A Fink; John A Robbins; Jane A Cauley; Annette L Fitzpatrick
Journal:  J Clin Endocrinol Metab       Date:  2014-08-22       Impact factor: 5.958

Review 8.  Lipids, oxidized lipids, oxidation-specific epitopes, and Age-related Macular Degeneration.

Authors:  James T Handa; Marisol Cano; Lei Wang; Sayantan Datta; Tongyun Liu
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2016-07-30       Impact factor: 4.698

Review 9.  Update on depression and age-related macular degeneration.

Authors:  Robin J Casten; Barry W Rovner
Journal:  Curr Opin Ophthalmol       Date:  2013-05       Impact factor: 3.761

10.  Association between depression and functional vision loss in persons 20 years of age or older in the United States, NHANES 2005-2008.

Authors:  Xinzhi Zhang; Kai McKeever Bullard; Mary Frances Cotch; M Roy Wilson; Barry W Rovner; Gerald McGwin; Cynthia Owsley; Lawrence Barker; John E Crews; Jinan B Saaddine
Journal:  JAMA Ophthalmol       Date:  2013-05       Impact factor: 7.389

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