Literature DB >> 19273183

PAI-1 and kidney fibrosis.

Li-Jun Ma1, Agnes B Fogo.   

Abstract

Substantial evidence demonstrates a link of increased plasminogen activator inhibitor-1 (PAI-1) and glomerulosclerosis and kidney fibrosis, providing a novel therapeutic option for prevention and treatment of chronic kidney diseases. Several mechanisms contributing to increased PAI-1 will be addressed, including classic key profibrotic factors such as the renin-angiotensin-system (RAS) and transforming growth factor-beta (TGF-b???and novel molecules identified by proteomic analysis, such as thymosin- b4. The fibrotic sequelae caused by increased PAI-1 in kidney depend not only on its classic inhibition of tissue-type and urokinase-type plasminogen activators (tPA and uPA), but also its influence on cell migration.

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Year:  2009        PMID： 19273183      PMCID： PMC4848749          DOI： 10.2741/3361

Source DB:  PubMed          Journal:  Front Biosci (Landmark Ed)        ISSN： 2768-6698


  121 in total

1.  Progression and potential regression of glomerulosclerosis.

Authors:  A B Fogo
Journal:  Kidney Int       Date:  2001-02       Impact factor: 10.612

2.  Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth.

Authors:  Xiu-Bin Liang; Li-Jun Ma; Takashi Naito; Yihan Wang; Michael Madaio; Roy Zent; Ambra Pozzi; Agnes B Fogo
Journal:  J Am Soc Nephrol       Date:  2006-06-21       Impact factor: 10.121

3.  Regression of renal vascular and glomerular fibrosis: role of angiotensin II receptor antagonism and matrix metalloproteinases.

Authors:  Jean-Jacques Boffa; Ying Lu; Sandrine Placier; Adam Stefanski; Jean-Claude Dussaule; Christos Chatziantoniou
Journal:  J Am Soc Nephrol       Date:  2003-05       Impact factor: 10.121

Review 4.  Pleiotropic functions of plasminogen activator inhibitor-1.

Authors:  H R Lijnen
Journal:  J Thromb Haemost       Date:  2005-01       Impact factor: 5.824

5.  Endogenous urokinase lacks antifibrotic activity during progressive renal injury.

Authors:  Ikuyo Yamaguchi; Jesus M Lopez-Guisa; Xiaohe Cai; Sarah J Collins; Daryl M Okamura; Allison A Eddy
Journal:  Am J Physiol Renal Physiol       Date:  2007-03-13

6.  Pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 attenuates angiotensin II/salt-induced aortic remodeling.

Authors:  Alec D Weisberg; Francisco Albornoz; Jane P Griffin; David L Crandall; Hassan Elokdah; Agnes B Fogo; Douglas E Vaughan; Nancy J Brown
Journal:  Arterioscler Thromb Vasc Biol       Date:  2004-12-02       Impact factor: 8.311

7.  Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene.

Authors:  D T Eitzman; R D McCoy; X Zheng; W P Fay; T Shen; D Ginsburg; R H Simon
Journal:  J Clin Invest       Date:  1996-01-01       Impact factor: 14.808

8.  Acute angiotensin-converting enzyme inhibition increases the plasma level of the natural stem cell regulator N-acetyl-seryl-aspartyl-lysyl-proline.

Authors:  M Azizi; A Rousseau; E Ezan; T T Guyene; S Michelet; J M Grognet; M Lenfant; P Corvol; J Ménard
Journal:  J Clin Invest       Date:  1996-02-01       Impact factor: 14.808

9.  Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.

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Journal:  Kidney Int       Date:  2006-01       Impact factor: 18.998

10.  Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins.

Authors:  Ralf-Peter Czekay; Kathleen Aertgeerts; Scott A Curriden; David J Loskutoff
Journal:  J Cell Biol       Date:  2003-03-03       Impact factor: 10.539
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  31 in total

1.  Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.

Authors:  Sha Hao; Weichun He; Yingjian Li; Hong Ding; Yayi Hou; Jing Nie; Fan Fan Hou; Michael Kahn; Youhua Liu
Journal:  J Am Soc Nephrol       Date:  2011-08-04       Impact factor: 10.121

Review 2.  Chronic kidney disease in the pathogenesis of acute ischemic stroke.

Authors:  Bharath Chelluboina; Raghu Vemuganti
Journal:  J Cereb Blood Flow Metab       Date:  2019-08-01       Impact factor: 6.200

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4.  Clusterin attenuates the development of renal fibrosis.

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Journal:  J Am Soc Nephrol       Date:  2011-11-03       Impact factor: 10.121

Review 5.  Tβ4-Ac-SDKP pathway: Any relevance for the cardiovascular system?

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Review 6.  Aldosterone and arterial hypertension.

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Journal:  Nat Rev Endocrinol       Date:  2009-12-22       Impact factor: 43.330

Review 7.  Causes and pathogenesis of focal segmental glomerulosclerosis.

Authors:  Agnes B Fogo
Journal:  Nat Rev Nephrol       Date:  2014-12-02       Impact factor: 28.314

Review 8.  PAI-1 in tissue fibrosis.

Authors:  Asish K Ghosh; Douglas E Vaughan
Journal:  J Cell Physiol       Date:  2012-02       Impact factor: 6.384

9.  Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/beta-catenin signaling.

Authors:  Weichun He; Ruoyun Tan; Chunsun Dai; Yingjian Li; Dan Wang; Sha Hao; Michael Kahn; Youhua Liu
Journal:  J Biol Chem       Date:  2010-06-02       Impact factor: 5.157

10.  High glucose forces a positive feedback loop connecting Akt kinase and FoxO1 transcription factor to activate mTORC1 kinase for mesangial cell hypertrophy and matrix protein expression.

Authors:  Falguni Das; Nandini Ghosh-Choudhury; Nirmalya Dey; Amit Bera; Meenalakshmi M Mariappan; Balakuntalam S Kasinath; Goutam Ghosh Choudhury
Journal:  J Biol Chem       Date:  2014-10-06       Impact factor: 5.157
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