| Literature DB >> 19272678 |
Jyoti Pandey1, Vinod K Tiwari, Shyam S Verma, Vinita Chaturvedi, S Bhatnagar, S Sinha, A N Gaikwad, Rama P Tripathi.
Abstract
A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization.Entities:
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Year: 2009 PMID： 19272678 DOI： 10.1016/j.ejmech.2009.02.013
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514