OBJECTIVES: The purpose of this study was to examine alterations in lipid profiles and in the serum concentrations of acylated and desacylated ghrelin, paraoxonase and arylesterase in psychiatric patients before and after treatment with 40 mg citalopram daily for 3 months. DESIGN AND METHODS: Samples were collected from 22 healthy controls and 24 psychiatric patients before and after citalopram treatment. Blood levels of acylated and desacylated ghrelin were measured by radioimmunoassay. Paraoxonase and arylesterase activities were determined spectrophotometrically. Lipid parameters were measured on the OLYMPUS-AU400. RESULTS: It was found that the levels of acylated, desacylated ghrelin, paraoxonase arylesterase, total cholesterol and triglyceride were lower in depressive patients before citalopram treatment than in the control group. Those parameters were not restored after citalopram treatment except for the arylesterase level. CONCLUSION: Decreased PON1 and ghrelin levels as well as fluctuations in lipid profiles may be involved in the etiology of depressive disorders.
OBJECTIVES: The purpose of this study was to examine alterations in lipid profiles and in the serum concentrations of acylated and desacylated ghrelin, paraoxonase and arylesterase in psychiatricpatients before and after treatment with 40 mg citalopram daily for 3 months. DESIGN AND METHODS: Samples were collected from 22 healthy controls and 24 psychiatricpatients before and after citalopram treatment. Blood levels of acylated and desacylated ghrelin were measured by radioimmunoassay. Paraoxonase and arylesterase activities were determined spectrophotometrically. Lipid parameters were measured on the OLYMPUS-AU400. RESULTS: It was found that the levels of acylated, desacylated ghrelin, paraoxonase arylesterase, total cholesterol and triglyceride were lower in depressivepatients before citalopram treatment than in the control group. Those parameters were not restored after citalopram treatment except for the arylesterase level. CONCLUSION: Decreased PON1 and ghrelin levels as well as fluctuations in lipid profiles may be involved in the etiology of depressive disorders.
Authors: O Giménez-Palop; R Coronas; J Cobo; L Gallart; J D Barbero; I Parra; G Fusté; J Vendrell; M Bueno; J M González-Clemente; A Caixàs Journal: J Endocrinol Invest Date: 2011-12-15 Impact factor: 4.256
Authors: Kimberly C Paul; Janet S Sinsheimer; Myles Cockburn; Jeff M Bronstein; Yvette Bordelon; Beate Ritz Journal: Environ Int Date: 2017-07-06 Impact factor: 9.621
Authors: Stina Börchers; Jean-Philippe Krieger; Ivana Maric; Jil Carl; Maral Abraham; Francesco Longo; Mohammed Asker; Jennifer E Richard; Karolina P Skibicka Journal: Front Endocrinol (Lausanne) Date: 2022-06-16 Impact factor: 6.055