OBJECTIVES: To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans. DESIGN AND METHODS: A total of 432 patients with MI and 430 controls were included in the study. Nine polymorphisms in the MTAP gene, two polymorphisms in the CDKN2A gene, and two polymorphisms in the CDKN2B gene were selected using a tagging single nucleotide polymorphism (tSNP) strategy. RESULTS: We observed that rs7027989 in the MTAP gene, and rs3217992 and rs1063192 in the CDKN2B gene were significantly associated with MI in male subjects. For rs7027989 and rs3217992, male subjects with the AA or AG genotypes had 1.26-fold and 1.24-fold increased risk of MI, respectively, compared with those with the GG genotype. For rs1063192, the G allele was associated with a reduced risk of MI with a per-allele OR of 0.71 in male subjects. The risk of rs7027989 and rs1063192 remained significant after adjusting for covariates. CONCLUSIONS: This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese.
OBJECTIVES: To investigate the association between cyclin-dependent kinase inhibitor 2A (CDKN2A) gene, cyclin-dependent kinase inhibitor 2B (CDKN2B) gene, and methylthioadenosine phosphorylase (MTAP) gene and myocardial infarction (MI) in Chinese Hans. DESIGN AND METHODS: A total of 432 patients with MI and 430 controls were included in the study. Nine polymorphisms in the MTAP gene, two polymorphisms in the CDKN2A gene, and two polymorphisms in the CDKN2B gene were selected using a tagging single nucleotide polymorphism (tSNP) strategy. RESULTS: We observed that rs7027989 in the MTAP gene, and rs3217992 and rs1063192 in the CDKN2B gene were significantly associated with MI in male subjects. For rs7027989 and rs3217992, male subjects with the AA or AG genotypes had 1.26-fold and 1.24-fold increased risk of MI, respectively, compared with those with the GG genotype. For rs1063192, the G allele was associated with a reduced risk of MI with a per-allele OR of 0.71 in male subjects. The risk of rs7027989 and rs1063192 remained significant after adjusting for covariates. CONCLUSIONS: This study demonstrates for the first time that polymorphisms in CDKN2B and MTAP gene may influence the risk of MI in Chinese.
Authors: Martin L Tomov; Zachary T Olmsted; Haluk Dogan; Eda Gongorurler; Maria Tsompana; Hasan H Otu; Michael Buck; Eun-Ah Chang; Jose Cibelli; Janet L Paluh Journal: Sci Rep Date: 2016-12-05 Impact factor: 4.379
Authors: Daniele Campa; Manuela Pastore; Manuel Gentiluomo; Renata Talar-Wojnarowska; Juozas Kupcinskas; Ewa Malecka-Panas; John P Neoptolemos; Willem Niesen; Pavel Vodicka; Gianfranco Delle Fave; H Bas Bueno-de-Mesquita; Maria Gazouli; Paola Pacetti; Milena Di Leo; Hidemi Ito; Harald Klüter; Pavel Soucek; Vincenzo Corbo; Kenji Yamao; Satoyo Hosono; Rudolf Kaaks; Yogesh Vashist; Domenica Gioffreda; Oliver Strobel; Yasuhiro Shimizu; Frederike Dijk; Angelo Andriulli; Audrius Ivanauskas; Peter Bugert; Francesca Tavano; Ludmila Vodickova; Carlo Federico Zambon; Martin Lovecek; Stefano Landi; Timothy J Key; Ugo Boggi; Raffaele Pezzilli; Krzysztof Jamroziak; Beatrice Mohelnikova-Duchonova; Andrea Mambrini; Franco Bambi; Olivier Busch; Valerio Pazienza; Roberto Valente; George E Theodoropoulos; Thilo Hackert; Gabriele Capurso; Giulia Martina Cavestro; Claudio Pasquali; Daniela Basso; Cosimo Sperti; Keitaro Matsuo; Markus Büchler; Kay-Tee Khaw; Jakob Izbicki; Eithne Costello; Verena Katzke; Christoph Michalski; Anna Stepien; Cosmeri Rizzato; Federico Canzian Journal: Oncotarget Date: 2016-08-30