| Literature DB >> 19271724 |
Gwendolyn A Marriner1, Sean M Kerwin.
Abstract
A concise and efficient route to (+/-)-N'-nitrosonornicotine 5'-acetate (NNN-5'-OAc), a stable precursor of the active metabolite 5'-hydroxy(+/-)-N'-nitrosonornicotine NNN-5'-OH is reported. The synthesis utilizes sulfinimine chemistry to give (+/-)-NNN-5'-OAc in 26% yield over 4 steps.Entities:
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Year: 2009 PMID： 19271724 DOI： 10.1021/jo9000417
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354