Literature DB >> 19270513

Malignant stem cells in childhood acute lymphoblastic leukemia: the stem cell concept revisited.

H Josef Vormoor1.   

Abstract

We have recently shown that in childhood acute lymphoblastic leukemia (ALL) blasts at different stages of immunophenotypic maturation possess stem cell properties. Here, we discuss our results in the context of previous investigations of ALL stem cells and recent studies highlighting specific limitations of the xenotransplantation models for human hematopoietic cells. Leukemia-propagating stem cells in ALL may be more frequent than previously thought!

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Year:  2009        PMID： 19270513     DOI： 10.4161/cc.8.7.7984

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  9 in total

1.  Recombinant human CD19L-sTRAIL effectively targets B cell precursor acute lymphoblastic leukemia.

Authors:  Fatih M Uckun; Dorothea E Myers; Sanjive Qazi; Zahide Ozer; Rebecca Rose; Osmond J D'Cruz; Hong Ma
Journal:  J Clin Invest       Date:  2015-01-26       Impact factor: 14.808

Review 2.  Acute lymphoblastic leukemia and developmental biology: a crucial interrelationship.

Authors:  Elena Campos-Sanchez; Amparo Toboso-Navasa; Isabel Romero-Camarero; Marcos Barajas-Diego; Isidro Sanchez-García; César Cobaleda
Journal:  Cell Cycle       Date:  2011-10-15       Impact factor: 4.534

3.  Flow minimal residual disease monitoring of candidate leukemic stem cells defined by the immunophenotype, CD34+CD38lowCD19+ in B-lineage childhood acute lymphoblastic leukemia.

Authors:  Kerrie Wilson; Marian Case; Lynne Minto; Simon Bailey; Nick Bown; Jenny Jesson; Sarah Lawson; Josef Vormoor; Julie Irving
Journal:  Haematologica       Date:  2009-11-30       Impact factor: 9.941

4.  CD19-antigen specific nanoscale liposomal formulation of a SYK P-site inhibitor causes apoptotic destruction of human B-precursor leukemia cells.

Authors:  Dorothea E Myers; Seang Yiv; Sanjive Qazi; Hong Ma; Ingrid Cely; Anoush Shahidzadeh; Martha Arellano; Erin Finestone; Paul S Gaynon; Amanda Termuhlen; Jianjun Cheng; Fatih M Uckun
Journal:  Integr Biol (Camb)       Date:  2014-08       Impact factor: 2.192

5.  High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias.

Authors:  S Morisot; A S Wayne; O Bohana-Kashtan; I M Kaplan; C D Gocke; R Hildreth; M Stetler-Stevenson; R L Walker; S Davis; P S Meltzer; S J Wheelan; P Brown; R J Jones; L D Shultz; C I Civin
Journal:  Leukemia       Date:  2010-08-26       Impact factor: 11.528

6.  Diverging fates of cells of origin in acute and chronic leukaemia.

Authors:  Boris Kovacic; Andrea Hoelbl; Gabriele Litos; Memetcan Alacakaptan; Christian Schuster; Katrin M Fischhuber; Marc A Kerenyi; Gabriele Stengl; Richard Moriggl; Veronika Sexl; Hartmut Beug
Journal:  EMBO Mol Med       Date:  2012-02-09       Impact factor: 12.137

7.  Individualized leukemia cell-population profiles in common B-cell acute lymphoblastic leukemia patients.

Authors:  Jian-Hua Yu; Jing-Tao Dong; Yong-Qian Jia; Neng-Gang Jiang; Ting-Ting Zeng; Hong Xu; Xian-Ming Mo; Wen-Tong Meng
Journal:  Chin J Cancer       Date:  2012-07-02

8.  Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations.

Authors:  Klaus Rehe; Kerrie Wilson; Simon Bomken; Daniel Williamson; Julie Irving; Monique L den Boer; Martin Stanulla; Martin Schrappe; Andrew G Hall; Olaf Heidenreich; Josef Vormoor
Journal:  EMBO Mol Med       Date:  2012-12-11       Impact factor: 12.137

9.  A cross-standardized flow cytometry platform to assess phenotypic stability in precursor B-cell acute lymphoblastic leukemia (B-ALL) xenografts.

Authors:  Nina Rolf; Lorraine Y T Liu; Angela Tsang; Philipp F Lange; Chinten James Lim; Christopher A Maxwell; Suzanne M Vercauteren; Gregor S D Reid
Journal:  Cytometry A       Date:  2021-06-25       Impact factor: 4.714
  9 in total

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