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Literature DB >> 19270089

vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.

Yongsheng Ma¹, Amy E Bryant, Dan B Salmi, Eric McIndoo, Dennis L Stevens.

Abstract

A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.

Entities: Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19270089 PMCID： PMC2681797 DOI： 10.1128/JB.01771-08

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

31 in total

1. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes.

Authors: Melody N Neely; William R Lyon; Donna L Runft; Michael Caparon
Journal: J Bacteriol Date: 2003-09 Impact factor: 3.490

2. Improved prediction of signal peptides: SignalP 3.0.

Authors: Jannick Dyrløv Bendtsen; Henrik Nielsen; Gunnar von Heijne; Søren Brunak
Journal: J Mol Biol Date: 2004-07-16 Impact factor: 5.469

3. Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes.

Authors: Michael S Chaussee; Gail L Sylva; Daniel E Sturdevant; Laura M Smoot; Morag R Graham; Robert O Watson; James M Musser
Journal: Infect Immun Date: 2002-02 Impact factor: 3.441

4. Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule.

Authors: B Kreikemeyer; M D Boyle; B A Buttaro; M Heinemann; A Podbielski
Journal: Mol Microbiol Date: 2001-01 Impact factor: 3.501

5. Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes.

Authors: Michelle A Chaussee; Eduardo A Callegari; Michael S Chaussee
Journal: J Bacteriol Date: 2004-11 Impact factor: 3.490

Review 6. Virulence factors of the group A streptococci and genes that regulate their expression.

Authors: Wayne Hynes
Journal: Front Biosci Date: 2004-09-01

7. An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes.

Authors: J Perez-Casal; J A Price; E Maguin; J R Scott
Journal: Mol Microbiol Date: 1993-05 Impact factor: 3.501

8. The Eagle effect revisited: efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis.

Authors: D L Stevens; A E Gibbons; R Bergstrom; V Winn
Journal: J Infect Dis Date: 1988-07 Impact factor: 5.226

9. Penicillin-binding protein expression at different growth stages determines penicillin efficacy in vitro and in vivo: an explanation for the inoculum effect.

Authors: D L Stevens; S Yan; A E Bryant
Journal: J Infect Dis Date: 1993-06 Impact factor: 5.226

10. Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A.

Authors: D L Stevens; M H Tanner; J Winship; R Swarts; K M Ries; P M Schlievert; E Kaplan
Journal: N Engl J Med Date: 1989-07-06 Impact factor: 91.245

7 in total

1. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

Authors: Samuel A Shelburne; Randall J Olsen; Nishanth Makthal; Nicholas G Brown; Pranoti Sahasrabhojane; Ebru M Watkins; Timothy Palzkill; James M Musser; Muthiah Kumaraswami
Journal: Mol Microbiol Date: 2011-11-21 Impact factor: 3.501

vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.

1. Role of RopB in growth phase expression of the SpeB cysteine protease of Streptococcus pyogenes.

2. Improved prediction of signal peptides: SignalP 3.0.

3. Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes.

4. Group A streptococcal growth phase-associated virulence factor regulation by a novel operon (Fas) with homologies to two-component-type regulators requires a small RNA molecule.

5. Rgg regulates growth phase-dependent expression of proteins associated with secondary metabolism and stress in Streptococcus pyogenes.

Review 6. Virulence factors of the group A streptococci and genes that regulate their expression.

7. An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes.

8. The Eagle effect revisited: efficacy of clindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis.

9. Penicillin-binding protein expression at different growth stages determines penicillin efficacy in vitro and in vivo: an explanation for the inoculum effect.

10. Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A.

1. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes.

2. CcpA and LacD.1 affect temporal regulation of Streptococcus pyogenes virulence genes.

3. Induction of a quorum sensing pathway by environmental signals enhances group A streptococcal resistance to lysozyme.

4. Genome-wide identification of genes required for fitness of group A Streptococcus in human blood.

5. Cationic antimicrobial peptides disrupt the Streptococcus pyogenes ExPortal.

6. Staphylococcus aureus α-hemolysin promotes platelet-neutrophil aggregate formation.

Review 7. Quorum sensing in group A Streptococcus.