| Literature DB >> 19269774 |
Md Zahidunnabi Dewan1, Masahiro Takada, Hiroshi Terunuma, Xuewen Deng, Sunjida Ahmed, Naoki Yamamoto, Masakazu Toi.
Abstract
Natural killer (NK) activity of immune cells plays a central role in host defense against cancer and virus-infected cells. Natural cytotoxic activity of peripheral-blood mononuclear cells was assessed by a Calcein-AM release assay in 89 subjects. In the present study, we here demonstrated that NK activities of peripheral-blood mononuclear cells (PBMCs) from breast cancer patients were significantly lower as compared with that of healthy individuals. There were significant differences in the NK activities of PBMCs from HER2-negative breast cancer patients as compared with HER2-positive patients. Our results suggest that NK activity of PBMCs is lower in breast cancer indicating a role for immunological natural host defense mechanisms against cancer.Entities:
Mesh：
Year: 2009 PMID： 19269774 DOI： 10.1016/j.biopha.2009.02.003
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529