Literature DB >> 192695

The effect of phosphonoacetic acid on the in vitro replication of varicella-zoster virus.

D C May, M R Miller, F Rapp.   

Abstract

Phosphonoacetic acid (PAA) was found to inhibit in vitro varicella-zoster virus (VZV) replication. At 100 microng/ml, PAA blocked the development and spread of VZV cytopathology in both growing and contact-inhibited cultures. Formation of virus plaques by infected cells and cell-free virus was effectively blocked at concentrations as low as 25 microng/ml. The development of nuclear and cytoplasmic virus antigens was also inhibited by PAA. Inhibition by PAA suggests that VZV DNA replication, like that of other herpes-viruses, involves a virus-specific DNA polymerase.

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Year:  1977        PMID： 192695     DOI： 10.1159/000148882

Source DB:  PubMed          Journal:  Intervirology        ISSN： 0300-5526            Impact factor:   1.763


  11 in total

1.  Phosphonoacetic acid in the treatment of simian varicella.

Authors:  A D Felsenfeld; C R Abee; P J Gerone; K F Soike; S R Williams
Journal:  Antimicrob Agents Chemother       Date:  1978-09       Impact factor: 5.191

2.  Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands.

Authors:  Jennifer T Miller; Haiyan Zhao; Takashi Masaoka; Brittany Varnado; Elena M Cornejo Castro; Vickie A Marshall; Kaivon Kouhestani; Anna Y Lynn; Keith E Aron; Anqi Xia; John A Beutler; Danielle R Hirsch; Liang Tang; Denise Whitby; Ryan P Murelli; Stuart F J Le Grice
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

3.  Synthesis and decay of varicella zoster virus transcripts.

Authors:  Yevgeniy Azarkh; Lars Dölken; Maria Nagel; Don Gilden; Randall J Cohrs
Journal:  J Neurovirol       Date:  2011-04-12       Impact factor: 2.643

4.  Postentry events are responsible for restriction of productive varicella-zoster virus infection in Chinese hamster ovary cells.

Authors:  Renée L Finnen; Kara R Mizokami; Bruce W Banfield; Guang-Yun Cai; Scott A Simpson; Lewis I Pizer; Myron J Levin
Journal:  J Virol       Date:  2006-11       Impact factor: 5.103

5.  Susceptibility of vaccine strains of varicella-zoster virus to antiviral compounds.

Authors:  S R Preblud; A M Arbeter; E A Proctor; S E Starr; S A Plotkin
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

6.  Virus replication and localization of varicella-zoster virus antigens in human embryonic fibroblast cells infected with cell-free virus.

Authors:  K Yamanishi; Y Matsunaga; T Ogino; M Takahashi; A Takamizawa
Journal:  Infect Immun       Date:  1980-05       Impact factor: 3.441

7.  Varicella-zoster virus infection induces autophagy in both cultured cells and human skin vesicles.

Authors:  Marie-Noëlle Takahashi; Wallen Jackson; Donna T Laird; Timothy D Culp; Charles Grose; John I Haynes; Luca Benetti
Journal:  J Virol       Date:  2009-03-18       Impact factor: 5.103

8.  Dose-related effect of acetylsalicylic acid on replication of varicella zoster virus in vitro.

Authors:  M A Walz-Cicconi; T H Weller
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

9.  In vitro and in vivo inhibition of myxoma virus by treatment with phosphonoacetic acid.

Authors:  J M Goodrich; K W Lee; H C Hinze
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574

10.  In vitro inhibition of Herpesvirus sylvilagus by phosphonoacetic acid and phosphonoformate.

Authors:  J M Goodrich; K W Lee; H C Hinze
Journal:  Arch Virol       Date:  1980       Impact factor: 2.574
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