| Literature DB >> 19269360 |
Abstract
Activation of plasma membrane calcium channels by depletion of endoplasmic reticulum (ER) calcium stores is important for calcium entry in many cell types. Park et al. (2009) now show that direct binding of the ER protein STIM to tetramers of the Orai1 calcium channel in the plasma membrane triggers opening of this channel.Entities:
Mesh:
Substances:
Year: 2009 PMID: 19269360 DOI: 10.1016/j.cell.2009.02.022
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582