Literature DB >> 1926757

DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases.

B C Padberg1, I Lauritzen, E Achilles, K Holl, M Bressel, G Klöppel, H Dralle, S Schröder.   

Abstract

Surgical specimens of 66 adrenocortical tumours were investigated by conventional microscopy and DNA cytophotometry. Histologically, 50 neoplasms were classified as adenomas and 16 as carcinomas. In only 8 of the latter cases were distant metastases and/or a lethal outcome recorded. On single cell scanning cytophotometry either non-euploid or aneuploid DNA histograms were identified in 24 of 50 adenomas (48%) and in 14 of 16 carcinomas (88%). The two carcinomas exhibiting euploid DNA distributions fell into the group of 7 malignancies which are recurrence-free so far. From these findings it is concluded that DNA measurements have no diagnostic and only limited prognostic value in neoplasms of the adrenal cortex.

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Year:  1991        PMID： 1926757     DOI： 10.1007/bf01626343

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  15 in total

1.  Adrenomedullary hyperplasia and phaeochromocytoma. DNA cytophotometric findings in 47 cases.

Authors:  B C Padberg; E Garbe; E Achilles; H Dralle; M Bressel; S Schröder
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1990

2.  Adrenocortical carcinoma: nuclear deoxyribonucleic acid ploidy studied by flow cytometry.

Authors:  Y Hosaka; L M Rainwater; C S Grant; W F Young; G M Farrow; J A van Heerden; M M Lieber
Journal:  Surgery       Date:  1987-12       Impact factor: 3.982

3.  Adrenal cortical neoplasms producing cushing's syndrome. A clinicopathologic study.

Authors:  D E Schteingart; H A Oberman; B A Friedman; J W Conn
Journal:  Cancer       Date:  1968-11       Impact factor: 6.860

4.  Cellular DNA profiles of benign and malignant adrenocortical tumors.

Authors:  E S Cibas; L J Medeiros; D S Weinberg; A B Gelb; L M Weiss
Journal:  Am J Surg Pathol       Date:  1990-10       Impact factor: 6.394

5.  Prognostic factors in adrenal cortical tumors. A mathematical analysis of clinical and morphologic data.

Authors:  A J Hough; J W Hollifield; D L Page; W H Hartmann
Journal:  Am J Clin Pathol       Date:  1979-09       Impact factor: 2.493

6.  The significance of DNA distribution pattern in rectal carcinoma. A preliminary study.

Authors:  G Forsslund; B Cedermark; U Ohman; K Erhardt; A Zetterberg; G Auer
Journal:  Dis Colon Rectum       Date:  1984-09       Impact factor: 4.585

7.  Flow cytometric analysis of adrenal cortical tumor DNA. Relationship between cellular DNA and histopathologic classification.

Authors:  L S Bowlby; L E DeBault; S R Abraham
Journal:  Cancer       Date:  1986-10-01       Impact factor: 6.860

8.  Flow cytometric analysis of nuclear DNA from adrenocortical neoplasms. A retrospective study using paraffin-embedded tissue.

Authors:  J B Amberson; E D Vaughan; G F Gray; G J Naus
Journal:  Cancer       Date:  1987-06-15       Impact factor: 6.860

9.  A small adrenocortical carcinoma with aggressive behavior. An evaluation of criteria for malignancy.

Authors:  M J Gandour; W E Grizzle
Journal:  Arch Pathol Lab Med       Date:  1986-11       Impact factor: 5.534

10.  DNA aneuploidy in adenomas of endocrine organs.

Authors:  H Joensuu; P J Klemi
Journal:  Am J Pathol       Date:  1988-07       Impact factor: 4.307
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  4 in total

1.  Immunocytochemistry in adrenocortical tumours: a clinicomorphological study of 72 neoplasms.

Authors:  S Schröder; B C Padberg; E Achilles; K Holl; H Dralle; G Klöppel
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1992

2.  Nuclear DNA patterns in adrenal cortex proliferative lesions.

Authors:  S Díaz-Cano; R González-Cámpora; J J Ríos-Martín; E Lerma-Puertas; M Jordà-Heras; F Vázquez-Ramírez; M Bibbo; H Galera-Davidson
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

3.  Nuclear DNA content and morphological characteristics in the prognosis of adrenocortical carcinoma.

Authors:  H R Haak; C J Cornelisse; J Hermans; L Cobben; G J Fleuren
Journal:  Br J Cancer       Date:  1993-07       Impact factor: 7.640

4.  Allelic loss at 19q12 and Xq11-12 predict an adverse clinical outcome in patients with mucinous ovarian tumours of low malignant potential.

Authors:  K Nakayama; Y Takebayashi; K Hata; R Fujiwaki; K Iida; M Fukumoto; K Miyazaki
Journal:  Br J Cancer       Date:  2004-03-22       Impact factor: 7.640
  4 in total

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