Literature DB >> 19267128

Chrysotile biopersistence: the misuse of biased studies.

Henri Pezerat1.   

Abstract

Although it is widely accepted that exposure to any asbestos type can increase the likelihood of lung cancer, mesothelioma, and non-malignant lung and pleural disorders, manufacturers and some chrysotile miners' unions contend that chrysotile either does not cause disease or that there is insufficient evidence to reach a conclusion. At the same time, Dr. D.M. Bernstein has published several animal studies, financed by the Québec Chrysotile Institute, to determine chrysotile biopersistence in the lungs. Bernstein's study protocol induces a very short fiber half-life, from which he concludes weak chrysotile carcinogenicity. Bernstein's findings contradict results obtained by independent scientists. Bernstein's results can only be explained by an aggressive pre-treatment of fibers, inducing many faults and fragility in the fibers' structure, leading to rapid hydration and breaking of long fibers in the lungs.

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Year:  2009        PMID: 19267128     DOI: 10.1179/107735209799449770

Source DB:  PubMed          Journal:  Int J Occup Environ Health        ISSN: 1077-3525


  6 in total

1.  Mortality in a Chinese chrysotile miner cohort.

Authors:  Xiaorong Wang; Sihao Lin; Eiji Yano; Hong Qiu; Igtanius T S Yu; Lapah Tse; Yajia Lan; Mianzhen Wang
Journal:  Int Arch Occup Environ Health       Date:  2011-07-28       Impact factor: 3.015

2.  Chrysotile effects on the expression of anti-oncogene P53 and P16 and oncogene C-jun and C-fos in Wistar rats' lung tissues.

Authors:  Yan Cui; Yuchan Wang; Jianjun Deng; Gongli Hu; Faqin Dong; Qingbi Zhang
Journal:  Environ Sci Pollut Res Int       Date:  2017-09-13       Impact factor: 4.223

3.  Cancer mortality in Chinese chrysotile asbestos miners: exposure-response relationships.

Authors:  Xiaorong Wang; Eiji Yano; Sihao Lin; Ignatius T S Yu; Yajia Lan; Lap Ah Tse; Hong Qiu; David C Christiani
Journal:  PLoS One       Date:  2013-08-21       Impact factor: 3.240

Review 4.  Quantification of short and long asbestos fibers to assess asbestos exposure: a review of fiber size toxicity.

Authors:  Guillaume Boulanger; Pascal Andujar; Jean-Claude Pairon; Marie-Annick Billon-Galland; Chantal Dion; Pascal Dumortier; Patrick Brochard; Annie Sobaszek; Pierre Bartsch; Christophe Paris; Marie-Claude Jaurand
Journal:  Environ Health       Date:  2014-07-21       Impact factor: 5.984

5.  How can the integrity of occupational and environmental health research be maintained in the presence of conflicting interests?

Authors:  Xaver Baur; Colin L Soskolne; Lisa A Bero
Journal:  Environ Health       Date:  2019-11-04       Impact factor: 5.984

6.  Ongoing downplaying of the carcinogenicity of chrysotile asbestos by vested interests.

Authors:  Xaver Baur; Arthur L Frank
Journal:  J Occup Med Toxicol       Date:  2021-02-23       Impact factor: 2.646

  6 in total

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