Literature DB >> 1926663

Toxicity of litholytic ethylenediaminetetraacetic acid solutions to the urothelium of the rat and dog.

W Oosterlinck1, R Verbeeck, C Cuvelier, H Verplaetse, A Verbaeys.   

Abstract

The toxicity to the urothelium of bipotassium ethylene-diaminetetraacetic acid (K2-EDTA) buffered with 0.2 M triethanolamine (TEA) at pH 8 and 8.5 was tested in rats and dogs. Even at a low concentration of 3.125 mM, K2-EDTA is very noxious to the bladder mucosa. This toxicity is not due to the buffer TEA, which is well tolerated. Although buffered K2-EDTA, at pH 8.5 is an excellent chemolytic agent for calcium-containing stones, its clinical use is limited by this toxicity.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1926663     DOI： 10.1007/bf00305309

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  5 in total

1.  Dissolution of urinary calculi.

Authors:  H I SUBY
Journal:  J Urol       Date:  1952-07       Impact factor: 7.450

2.  Modern aspects of chemical dissolution of human renal calculi by irrigation.

Authors:  A Timmermann; G Kallistratos
Journal:  J Urol       Date:  1966-04       Impact factor: 7.450

3.  Solubility of inorganic kidney stone components in the presence of acid-base sensitive complexing agents.

Authors:  H Verplaetse; R M Verbeeck; H Minnaert; W Oosterlinck
Journal:  Eur Urol       Date:  1985       Impact factor: 20.096

4.  Solubility of calcium oxalate monohydrate and hydroxyapatite in EDTA solutions.

Authors:  H Verplaetse; R M Verbeeck; A Verbaeys; W Oosterlinck
Journal:  J Urol       Date:  1986-03       Impact factor: 7.450

5.  Urothelial injury from ethylenediaminetetraacetic acid used as an irrigant in the urinary tract.

Authors:  M H Kane; J S Rodman; B Horten; J Reckler; D Marion; E D Vaughan
Journal:  J Urol       Date:  1989-11       Impact factor: 7.450
  5 in total
  3 in total

1.  Rationale for local toxicity of calcium chelators.

Authors:  W Oosterlinck; R Verbeeck; C Cuvelier; D Vergauwe
Journal:  Urol Res       Date:  1992

2.  Protection of HIV neutralizing aptamers against rectal and vaginal nucleases: implications for RNA-based therapeutics.

Authors:  Michael D Moore; Jonathan Cookson; Veronica K Coventry; Brian Sproat; Lorna Rabe; Ross D Cranston; Ian McGowan; William James
Journal:  J Biol Chem       Date:  2010-11-24       Impact factor: 5.157

3.  Therapeutic use of tetrasodium ethylenediaminetetraacetic acid solution for treatment of subcutaneous ureteral bypass device mineralization in cats.

Authors:  Colin Chik; Allyson C Berent; Chick W Weisse; Marcia Ryder
Journal:  J Vet Intern Med       Date:  2019-08-06       Impact factor: 3.333
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.