OBJECTIVE: We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. DESIGN: Hospital-based case-control study. SETTING: Six tertiary medical institutes in Korea. POPULATION: Forty-five epithelial ovarian cancers and 135 age-matched controls. METHODS: Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. MAIN OUTCOME MEASURES: Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. RESULTS: Women in the highest tertile for beta-carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), alpha-tocopherol (OR 0.23; 95%CI 0.10-0.53) and gamma-tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. CONCLUSIONS: Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, alpha-tocopherol, and gamma-tocopherol, may play a role in reducing the risk of ovarian cancer.
OBJECTIVE: We investigated the relation between plasma carotenoids, retinol and tocopherol levels and ovarian cancer risk in Korean women. DESIGN: Hospital-based case-control study. SETTING: Six tertiary medical institutes in Korea. POPULATION: Forty-five epithelial ovarian cancers and 135 age-matched controls. METHODS: Preoperative plasma concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol were measured by reverse-phase, gradient high-pressure liquid chromatography. MAIN OUTCOME MEASURES: Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated by tertiles to evaluate the effect of micronutrients on endometrial cancer risk after adjustment for body mass (BMI) index, menopause, parity, oral contraceptive use, smoking status, and alcohol consumption status. RESULTS:Women in the highest tertile for beta-carotene had 0.12-times the risk of ovarian cancer of in the lowest tertile (OR 0.12; 95%CI 0.04-0.36). Women with the highest tertiles of lycopene (OR 0.09; 95%CI 0.03-0.32), zeaxanthin/lutein (OR 0.21; 95%CI 0.09-0.52), retinol (OR 0.45; 95%CI 0.21-0.98), alpha-tocopherol (OR 0.23; 95%CI 0.10-0.53) and gamma-tocopherol (OR 0.28; 95%CI 0.11-0.70) had lower risk of ovarian cancer than women in the lowest tertiles. Results were consistent across strata of socio-epidemiologic factors. CONCLUSIONS: Micronutrients, specifically ss-carotene, lycopene, zeaxanthin, lutein, retinol, alpha-tocopherol, and gamma-tocopherol, may play a role in reducing the risk of ovarian cancer.
Authors: Paul D Terry; Bo Qin; Fabian Camacho; Patricia G Moorman; Anthony J Alberg; Jill S Barnholtz-Sloan; Melissa Bondy; Michele L Cote; Ellen Funkhouser; Kristin A Guertin; Edward S Peters; Ann G Schwartz; Joellen M Schildkraut; Elisa V Bandera Journal: J Nutr Date: 2017-02-15 Impact factor: 4.798
Authors: Dina Gifkins; Sara H Olson; Lisa Paddock; Melony King; Kitaw Demissie; Shou-En Lu; Ah-Ng Tony Kong; Lorna Rodriguez-Rodriguez; Elisa V Bandera Journal: BMC Cancer Date: 2012-06-01 Impact factor: 4.430
Authors: Kazim Sahin; Engin Yenice; Mehmet Tuzcu; Cemal Orhan; Cengizhan Mizrak; Ibrahim H Ozercan; Nurhan Sahin; Bahiddin Yilmaz; Birdal Bilir; Bulent Ozpolat; Omer Kucuk Journal: J Cancer Prev Date: 2018-03-30
Authors: Vlad Moisoiu; Andrei Stefancu; Diana Gulei; Radu Boitor; Lorand Magdo; Lajos Raduly; Sergiu Pasca; Paul Kubelac; Nikolay Mehterov; Vasile Chiș; Marioara Simon; Mihai Muresan; Alexandra Iulia Irimie; Mihaela Baciut; Rares Stiufiuc; Ioana E Pavel; Patriciu Achimas-Cadariu; Calin Ionescu; Vladimir Lazar; Victoria Sarafian; Ioan Notingher; Nicolae Leopold; Ioana Berindan-Neagoe Journal: Int J Nanomedicine Date: 2019-08-02