| Literature DB >> 19265430 |
Taridaporn Bunyapaiboonsri1, Seangaroon Yoiprommarat, Kamolphan Intereya, Pranee Rachtawee, Nigel L Hywel-Jones, Masahiko Isaka.
Abstract
New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.Entities:
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Year: 2009 PMID： 19265430 DOI： 10.1021/np800702c
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050