Esther S Veldhoen1, Barend J Hartman, Josephus P J van Gestel. 1. Department of Pediatrics, The Pediatric Intensive Care Unit, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands. e.s.veldhoen@umcutrecht.nl
Abstract
OBJECTIVE: The aim of this report is to describe a fatal case of propofol infusion syndrome (PRIS), despite regular screening for this syndrome and immediate discontinuation of the infusion after the first signs of biochemical derangement. DESIGN: Case report. SETTING: Pediatric intensive care unit. PATIENT: A 17-year-old patient admitted after sustaining a traumatic brain injury. INTERVENTIONS: Treatment for traumatic brain injury was given with mechanical ventilation, inotropic support, mannitol, and sedation with propofol. Blood gases and serum levels of lactate and creatine kinase were monitored frequently to screen for PRIS. MEASUREMENTS AND MAIN RESULTS: Propofol infusion was stopped immediately after the first signs of biochemical derangement. The patient died despite supportive treatment with intra-aortic balloon pump and cardiopulmonary resuscitation. CONCLUSIONS: This case report demonstrates that frequent monitoring of biochemical parameters, as suggested in literature, cannot always prevent death due to PRIS.
OBJECTIVE: The aim of this report is to describe a fatal case of propofol infusion syndrome (PRIS), despite regular screening for this syndrome and immediate discontinuation of the infusion after the first signs of biochemical derangement. DESIGN: Case report. SETTING: Pediatric intensive care unit. PATIENT: A 17-year-old patient admitted after sustaining a traumatic brain injury. INTERVENTIONS: Treatment for traumatic brain injury was given with mechanical ventilation, inotropic support, mannitol, and sedation with propofol. Blood gases and serum levels of lactate and creatine kinase were monitored frequently to screen for PRIS. MEASUREMENTS AND MAIN RESULTS:Propofol infusion was stopped immediately after the first signs of biochemical derangement. The patient died despite supportive treatment with intra-aortic balloon pump and cardiopulmonary resuscitation. CONCLUSIONS: This case report demonstrates that frequent monitoring of biochemical parameters, as suggested in literature, cannot always prevent death due to PRIS.
Authors: Patrick Van de Voorde; Arnaud Van Lander; Kirsten Colpaert; Ann Verrijckt; Evelyn Dhont; Annick De Jaeger Journal: Intensive Care Med Date: 2013-08-16 Impact factor: 17.440
Authors: Steven C Mehl; Megan E Cunningham; Michael D Chance; Huirong Zhu; Sara C Fallon; Bindi Naik-Mathuria; Nicholas A Ettinger; Adam M Vogel Journal: Pediatr Surg Int Date: 2021-12-01 Impact factor: 1.827