| Literature DB >> 19265133 |
Kyung-Eun Kim1, Hyunkeun Song, Candace Hahm, Sun Young Yoon, Sunyoung Park, Ha-reum Lee, Dae Young Hur, Taesung Kim, Cherl-hyun Kim, Sa Ik Bang, Jung-Wook Bang, Hyunjeong Park, Dae-Ho Cho.
Abstract
IL-18 has recently been reported to play a critical role in tumor migration, invasion, and metastasis. Because IL-18 has various biological activities after its secretion as an 18 kDa mature form, the regulation of the IL-18 secretion process is an important step in tumor progression. This study investigated the implication of IL-18 in vascular endothelial growth factor (VEGF)-D-regulated migration, along with the role of the IL-18 secretion process. VEGF-D enhanced cell migration, which was then blocked by inhibiting IL-18. VEGF-D increased IL-18 expression and secretion, suggesting that IL-18 is a critical mediator for VEGF-D-enhanced migration. VEGF-D induced a disintegrin and metalloprotease 33 (ADAM33) expression, which has a metalloproteinase domain. VEGF-D-enhanced IL-18 secretion and cell migration were inhibited by ADAM33 knock-down. Moreover, cell proliferation was considerably reduced in ADAM33 small interfering RNA transfectants. In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19265133 DOI： 10.4049/jimmunol.0801695
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422