| Literature DB >> 19264535 |
Ephraim Fass1, Eduardo A Groisman.
Abstract
The Salmonella Pathogenicity Island-2 (i.e. SPI-2) encodes a unique type III secretion system that delivers effector proteins from the Salmonella-containing vacuole (SCV) into the host cell. The SPI-2 locus also encodes translocated effectors as well as a two-component system - termed SpiR/SsrB - that is essential for the expression of SPI-2 genes. Transcription of the horizontally acquired SPI-2 genes requires the ancestral nucleoid-associated proteins (i.e. NAPs) IHF and Fis, the regulatory protein SlyA, and the two-component systems PhoP/PhoQ and OmpR/EnvZ, as well as the DNA binding protein HilD encoded in a different pathogenicity island. Some of these positive SPI-2 regulators act to antagonize the robust silencing promoted by the NAPs H-NS, Hha, and YdgT.Entities:
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Year: 2009 PMID： 19264535 PMCID： PMC2805070 DOI： 10.1016/j.mib.2009.01.004
Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934