| Literature DB >> 19264481 |
Britt-Marie Swahn1, Istvan Macsari, Jenny Viklund, Liselotte Ohberg, Johanna Sjödin, Jan Neelissen, Johanna Lindquist.
Abstract
The synthesis and SAR of a new series of LXR agonist is reported. The N-Aryl-3,3,3-trifluoro-2-hydroxy-2-methyl-propionamide hits were found in a limited screen of the AstraZeneca compound collection. The effort to optimize these hits into LXRbeta selectivity is described. Compound 20 displayed desirable pharmacokinetic profile and up regulation of ABCA1 and ABCG1 mRNA in the brain were achieved when evaluated in vivo in mice.Entities:
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Year: 2009 PMID： 19264481 DOI： 10.1016/j.bmcl.2009.02.039
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823