AIM: To investigate differences of platelet indices in breast cancer patients after tamoxifen (tmx) and anastrazole adjuvant treatment. METHODS: In this retrospective study, 46 postmenopausal women (20 with tmx and 26 with anastrazole) with breast cancer who received adjuvant hormone therapy were enrolled. The biochemical and complete blood count (CBC) parameters were documented before hormone treatment start and after 1 year. RESULTS: The lymphocyte count was higher after tmx use, but not anastrazole. Total white blood cells were increased both after 1-year tmx and anastrazole using. Mean platelet volume (MPV) increased after tmx use (8.2 +/- 0.94-8.97 +/- 0.97; P: 0.041), while it was not different after anastrazole use (7.96 +/- 1.08-7.89 +/- 0.99; P: 0.585). Other platelet parameters did not alter with tmx or anastrazole treatment. CONCLUSION: We found increased MPV after tmx treatment, but did not after anastrazole treatment. The advanced studies which explore biological significance of high MPV in breast cancer patients used endocrine therapy, should be established.
AIM: To investigate differences of platelet indices in breast cancerpatients after tamoxifen (tmx) and anastrazole adjuvant treatment. METHODS: In this retrospective study, 46 postmenopausal women (20 with tmx and 26 with anastrazole) with breast cancer who received adjuvant hormone therapy were enrolled. The biochemical and complete blood count (CBC) parameters were documented before hormone treatment start and after 1 year. RESULTS: The lymphocyte count was higher after tmx use, but not anastrazole. Total white blood cells were increased both after 1-year tmx and anastrazole using. Mean platelet volume (MPV) increased after tmx use (8.2 +/- 0.94-8.97 +/- 0.97; P: 0.041), while it was not different after anastrazole use (7.96 +/- 1.08-7.89 +/- 0.99; P: 0.585). Other platelet parameters did not alter with tmx or anastrazole treatment. CONCLUSION: We found increased MPV after tmx treatment, but did not after anastrazole treatment. The advanced studies which explore biological significance of high MPV in breast cancerpatients used endocrine therapy, should be established.
Authors: Antonio Muscari; Giovanni M Puddu; Andrea Cenni; Maria G Silvestri; Rosa Giuzio; Marzia Rosati; Nadia Santoro; Giampaolo Bianchi; Donatella Magalotti; Marco Zoli Journal: Thromb Res Date: 2008-05-09 Impact factor: 3.944
Authors: John F Forbes; Jack Cuzick; Aman Buzdar; Anthony Howell; Jeffrey S Tobias; Michael Baum Journal: Lancet Oncol Date: 2008-01 Impact factor: 41.316
Authors: Halil Taskaynatan; Ahmet Alacacioglu; Yuksel Kucukzeybek; Umut Varol; Yasar Yildiz; Tarik Salman; Utku Oflazoglu; Mustafa Oktay Tarhan Journal: Open Med (Wars) Date: 2018-10-04