| Literature DB >> 1926325 |
C van der Poel1, H Cuypers, H Reesink, Q L Choo, G Kuo, J Han, S Quan, A Polito, J Verstraten, J van de Wouw.
Abstract
Risk factors of parenteral and nonparenteral exposure to hepatitis C virus (HCV) infection were studied in 125 blood donors in The Netherlands who were positive for anti-HCV on enzyme-linked immunosorbent assay (ELISA). Risk factors were related to confirmatory test results of four-antigen recombinant immunoblot assay (4-RIBA) and polymerase chain reaction (PCR) of the HCV 5' untranslated region. Twelve (10%) of the 125 anti-HCV C100 ELISA-positive blood donors were 4-RIBA positive. Eleven (92%) of 12 4-RIBA-positive blood donors were PCR positive, and all 113 remaining 4-RIBA-negative or -indeterminate donors were PCR negative. Eleven (92%) of 12 4-RIBA-positive blood donors had a risk factor of parenteral exposure, as compared to 17 (15%) of 113 4-RIBA-negative or -indeterminate donors. The prevalence of confirmed HCV infection among Amsterdam blood donors is calculated at 0.04 percent; parenteral exposure appears to be the major risk factor for HCV infection.Entities:
Mesh：
Year: 1991 PMID： 1926325 DOI： 10.1046/j.1537-2995.1991.31892023508.x
Source DB: PubMed Journal: Transfusion ISSN： 0041-1132 Impact factor: 3.157