Masanori Adachi1, Koji Muroya, Yumi Asakura. 1. Department of Endocrinology and Metabolism, Clinical Research Institute, Kanagawa Children's Medical Center, Minami-ku, Yokohama, Japan. madachi@mars.sannet.ne.jp
Abstract
OBJECTIVE: The purpose of this study is to evaluate atherosclerotic potency among childhood cancer survivors (CCS) with suprasellar tumors. STUDY DESIGN: Patients with remitted suprasellar tumors were recruited. A total of 17 subjects with simple obesity of similar ages served as obese controls. Fasting sera were subjected to determination of lipids and apolipoproteins (Apo), including small dense LDL-cholesterol (sdLDL-C). RESULTS: Twenty-three patients (4-22 years old) were enrolled. Patients, 12/23, had a body mass index (BMI) above the 90th percentile and were designated as 'obese patients'. Obese patients had lower BMI scores (mean 26.4 kg/m(2), p < 0.01) compared to obese controls (mean 31.5 kg/m(2)). Both groups had identical levels of total cholesterol, triglycerides, LDL-C, and HDL-C. However, obese patients were found to have a higher incidence of Apo B/Apo A1 ratio elevation (6/12) than obese controls (0/17, p < 0.01). In addition, obese patients had higher sdLDL-C level (47.6 +/- 14.8 mg/dL) than obese controls (28.3 +/- 7.1 mg/dL, p < 0.01). BMI showed strong correlations with both the Apo B/Apo A1 ratio (r = 0.663, p < 0.001) and sdLDL-C (r = 0.606, p < 0.01). CONCLUSION: CCS with suprasellar tumors, especially patients with a high BMI, had an unfavorable lipoprotein profile characterized by increased Apo B and sdLDL-C.
OBJECTIVE: The purpose of this study is to evaluate atherosclerotic potency among childhood cancer survivors (CCS) with suprasellar tumors. STUDY DESIGN:Patients with remitted suprasellar tumors were recruited. A total of 17 subjects with simple obesity of similar ages served as obese controls. Fasting sera were subjected to determination of lipids and apolipoproteins (Apo), including small dense LDL-cholesterol (sdLDL-C). RESULTS: Twenty-three patients (4-22 years old) were enrolled. Patients, 12/23, had a body mass index (BMI) above the 90th percentile and were designated as 'obesepatients'. Obesepatients had lower BMI scores (mean 26.4 kg/m(2), p < 0.01) compared to obese controls (mean 31.5 kg/m(2)). Both groups had identical levels of total cholesterol, triglycerides, LDL-C, and HDL-C. However, obesepatients were found to have a higher incidence of Apo B/Apo A1 ratio elevation (6/12) than obese controls (0/17, p < 0.01). In addition, obesepatients had higher sdLDL-C level (47.6 +/- 14.8 mg/dL) than obese controls (28.3 +/- 7.1 mg/dL, p < 0.01). BMI showed strong correlations with both the Apo B/Apo A1 ratio (r = 0.663, p < 0.001) and sdLDL-C (r = 0.606, p < 0.01). CONCLUSION: CCS with suprasellar tumors, especially patients with a high BMI, had an unfavorable lipoprotein profile characterized by increased Apo B and sdLDL-C.
Authors: Maria C Swartz; Karen M Basen-Engquist; Christine Markham; Elizabeth J Lyons; Matthew Cox; Joya Chandra; Joann L Ater; Martha A Askins; Michael E Scheurer; Philip J Lupo; Rachel Hill; Jeffrey Murray; Wenyaw Chan; Paul R Swank Journal: J Adolesc Young Adult Oncol Date: 2016-04-04 Impact factor: 2.223