Literature DB >> 19262151

Putting the brakes on cancer cell migration: JAM-A restrains integrin activation.

Ulhas P Naik1, Meghna U Naik.   

Abstract

Junctional Adhesion Molecule A (JAM-A) is a member of the Ig superfamily of membrane proteins expressed in platelets, leukocytes, endothelial cells and epithelial cells. We have previously shown that in endothelial cells, JAM-A regulates basic fibroblast growth factor, (FGF-2)-induced angiogenesis via augmenting endothelial cell migration. Recently, we have revealed that in breast cancer cells, downregulation of JAM-A enhances cancer cell migration and invasion. Further, ectopic expression of JAM-A in highly metastatic MDA-MB-231 cells attenuates cell migration, and downregulation of JAM-A in low-metastatic T47D cells enhance migration. Interestingly, JAM-A expression is greatly diminished as breast cancer disease progresses. The molecular mechanism of this function of JAM-A is beyond its well-characterized barrier function at the tight junction. Our results point out that JAM-A differentially regulates migration of endothelial and cancer cells.

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Year:  2008        PMID： 19262151      PMCID： PMC2633686          DOI： 10.4161/cam.2.4.6753

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  38 in total

1.  X-ray structure of junctional adhesion molecule: structural basis for homophilic adhesion via a novel dimerization motif.

Authors:  D Kostrewa; M Brockhaus; A D'Arcy; G E Dale; P Nelboeck; G Schmid; F Mueller; G Bazzoni; E Dejana; T Bartfai; F K Winkler; M Hennig
Journal:  EMBO J       Date:  2001-08-15       Impact factor: 11.598

Review 2.  Signalling to and from tight junctions.

Authors:  Karl Matter; Maria S Balda
Journal:  Nat Rev Mol Cell Biol       Date:  2003-03       Impact factor: 94.444

Review 3.  The JAM family of junctional adhesion molecules.

Authors:  Gianfranco Bazzoni
Journal:  Curr Opin Cell Biol       Date:  2003-10       Impact factor: 8.382

Review 4.  Junctional adhesion molecule 1 (JAM-1).

Authors:  U P Naik; K Eckfeld
Journal:  J Biol Regul Homeost Agents       Date:  2003 Oct-Dec       Impact factor: 1.711

5.  JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.

Authors:  Georg Ostermann; Kim S C Weber; Alma Zernecke; Andreas Schröder; Christian Weber
Journal:  Nat Immunol       Date:  2002-01-14       Impact factor: 25.606

6.  Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1.

Authors:  K Ebnet; C U Schulz; M K Meyer Zu Brickwedde; G G Pendl; D Vestweber
Journal:  J Biol Chem       Date:  2000-09-08       Impact factor: 5.157

7.  Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow.

Authors:  S K Shaw; B N Perkins; Y C Lim; Y Liu; A Nusrat; F J Schnell; C A Parkos; F W Luscinskas
Journal:  Am J Pathol       Date:  2001-12       Impact factor: 4.307

8.  Homophilic interaction of junctional adhesion molecule.

Authors:  G Bazzoni; O M Martinez-Estrada; F Mueller; P Nelboeck; G Schmid; T Bartfai; E Dejana; M Brockhaus
Journal:  J Biol Chem       Date:  2000-10-06       Impact factor: 5.157

9.  Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex.

Authors:  Meghna U Naik; Shaker A Mousa; Charles A Parkos; Ulhas P Naik
Journal:  Blood       Date:  2003-05-15       Impact factor: 22.113

10.  Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration.

Authors:  Meghna U Naik; Deepika Vuppalanchi; Ulhas P Naik
Journal:  Arterioscler Thromb Vasc Biol       Date:  2003-09-04       Impact factor: 8.311
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  8 in total

Review 1.  Tight junctions in lung cancer and lung metastasis: a review.

Authors:  Ylermi Soini
Journal:  Int J Clin Exp Pathol       Date:  2012-02-12

2.  Development of a Fluorescent Reporter System to Delineate Cancer Stem Cells in Triple-Negative Breast Cancer.

Authors:  Justin D Lathia; Ofer Reizes; Praveena S Thiagarajan; Masahiro Hitomi; James S Hale; Alvaro G Alvarado; Balint Otvos; Maksim Sinyuk; Kevin Stoltz; Andrew Wiechert; Erin Mulkearns-Hubert; Awad Jarrar; Qiao Zheng; Dustin Thomas; Thomas Egelhoff; Jeremy N Rich; Huiping Liu
Journal:  Stem Cells       Date:  2015-05-15       Impact factor: 6.277

Review 3.  Dysregulation of JAM-A plays an important role in human tumor progression.

Authors:  Chen Zhao; Funian Lu; Hongxia Chen; Xianda Zhao; Jun Sun; Honglei Chen
Journal:  Int J Clin Exp Pathol       Date:  2014-09-15

4.  Expression of tight junction molecules in breast carcinomas analysed by array PCR and immunohistochemistry.

Authors:  Anna-Mária Tőkés; Attila Marcell Szász; Eva Juhász; Zsuzsa Schaff; László Harsányi; István Arthur Molnár; Zsolt Baranyai; István Besznyák; Attila Zaránd; Ferenc Salamon; Janina Kulka
Journal:  Pathol Oncol Res       Date:  2011-12-23       Impact factor: 3.201

5.  High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor.

Authors:  Justin D Lathia; Meizhang Li; Maksim Sinyuk; Alvaro G Alvarado; William A Flavahan; Kevin Stoltz; Ann Mari Rosager; James Hale; Masahiro Hitomi; Joseph Gallagher; Qiulian Wu; Jody Martin; Jason G Vidal; Ichiro Nakano; Rikke H Dahlrot; Steinbjørn Hansen; Roger E McLendon; Andrew E Sloan; Shideng Bao; Anita B Hjelmeland; Christian T Carson; Ulhas P Naik; Bjarne Kristensen; Jeremy N Rich
Journal:  Cell Rep       Date:  2013-12-27       Impact factor: 9.423

6.  ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.

Authors:  Olga Tornavaca; Minghao Chia; Neil Dufton; Lourdes Osuna Almagro; Daniel E Conway; Anna M Randi; Martin A Schwartz; Karl Matter; Maria S Balda
Journal:  J Cell Biol       Date:  2015-03-09       Impact factor: 10.539

Review 7.  The Roles of Junctional Adhesion Molecules (JAMs) in Cell Migration.

Authors:  Junqi Wang; Han Liu
Journal:  Front Cell Dev Biol       Date:  2022-03-09

8.  CD146 expression in human breast cancer cell lines induces phenotypic and functional changes observed in Epithelial to Mesenchymal Transition.

Authors:  Anne-Marie Imbert; Celine Garulli; Elodie Choquet; Myriam Koubi; Michel Aurrand-Lions; Christian Chabannon
Journal:  PLoS One       Date:  2012-08-30       Impact factor: 3.240
  8 in total

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