Literature DB >> 19262123

Collective invasion of carcinoma cells: when the fibroblasts take the lead.

Cedric Gaggioli1.   

Abstract

Epithelial to mesenchymal transitions (EMT) have been suggested to be crucial during epithelial cancer cell invasion. However, in a three-dimensional "organotypic" invasion assay squamous cell carcinoma (SCC) cells that retain epithelial characteristics "hitch a ride" with carcinoma associated fibroblasts (CAFs) in order to collectively invade. Thus epithelial cancer cells can utilise the mesenchymal characteristics of CAFs without the need to undergo EMT themselves. This work provides new insight in cancer cell invasion and shows a new role for CAFs as a target for an anti-invasive therapy.

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Year:  2008        PMID： 19262123      PMCID： PMC2635002          DOI： 10.4161/cam.2.1.5705

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  20 in total

Review 1.  Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

Authors:  Christopher M Overall; Oded Kleifeld
Journal:  Nat Rev Cancer       Date:  2006-03       Impact factor: 60.716

Review 2.  Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment.

Authors:  Joyce C Tse; Raghu Kalluri
Journal:  J Cell Biochem       Date:  2007-07-01       Impact factor: 4.429

3.  Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.

Authors:  Akira Orimo; Piyush B Gupta; Dennis C Sgroi; Fernando Arenzana-Seisdedos; Thierry Delaunay; Rizwan Naeem; Vincent J Carey; Andrea L Richardson; Robert A Weinberg
Journal:  Cell       Date:  2005-05-06       Impact factor: 41.582

Review 4.  Fibroblasts in cancer.

Authors:  Raghu Kalluri; Michael Zeisberg
Journal:  Nat Rev Cancer       Date:  2006-05       Impact factor: 60.716

5.  p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism.

Authors:  I R Macpherson; S Hooper; A Serrels; L McGarry; B W Ozanne; K Harrington; M C Frame; E Sahai; V G Brunton
Journal:  Oncogene       Date:  2007-03-05       Impact factor: 9.867

6.  Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.

Authors:  Katarina Wolf; Yi I Wu; Yueying Liu; Jörg Geiger; Eric Tam; Christopher Overall; M Sharon Stack; Peter Friedl
Journal:  Nat Cell Biol       Date:  2007-07-08       Impact factor: 28.824

7.  Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton.

Authors:  X D Ren; W B Kiosses; M A Schwartz
Journal:  EMBO J       Date:  1999-02-01       Impact factor: 11.598

Review 8.  Stromal fibroblasts in cancer initiation and progression.

Authors:  Neil A Bhowmick; Eric G Neilson; Harold L Moses
Journal:  Nature       Date:  2004-11-18       Impact factor: 49.962

9.  Integrins control motile strategy through a Rho-cofilin pathway.

Authors:  Erik H J Danen; Jacco van Rheenen; Willeke Franken; Stephan Huveneers; Petra Sonneveld; Kees Jalink; Arnoud Sonnenberg
Journal:  J Cell Biol       Date:  2005-05-02       Impact factor: 10.539

10.  alpha v beta3 and alpha5beta1 integrin recycling pathways dictate downstream Rho kinase signaling to regulate persistent cell migration.

Authors:  Dominic P White; Patrick T Caswell; Jim C Norman
Journal:  J Cell Biol       Date:  2007-05-07       Impact factor: 10.539
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  21 in total

Review 1.  Divide or Conquer: Cell Cycle Regulation of Invasive Behavior.

Authors:  Abraham Q Kohrman; David Q Matus
Journal:  Trends Cell Biol       Date:  2016-09-12       Impact factor: 20.808

2.  An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation.

Authors:  Dolores Di Vizio; Matteo Morello; Federica Sotgia; Richard G Pestell; Michael R Freeman; Michael P Lisanti
Journal:  Cell Cycle       Date:  2009-08-27       Impact factor: 4.534

Review 3.  Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment.

Authors:  Ying Xiong; Lindsay T McDonald; Dayvia L Russell; Ryan R Kelly; Katie R Wilson; Meenal Mehrotra; Adam C Soloff; Amanda C LaRue
Journal:  World J Stem Cells       Date:  2015-03-26       Impact factor: 5.326

4.  Dural Cells Release Factors Which Promote Cancer Cell Malignancy and Induce Immunosuppressive Markers in Bone Marrow Myeloid Cells.

Authors:  Nicholas J Szerlip; Alexandra Calinescu; Eleanor Smith; Rebecca Tagett; Katrina L Clines; Henry H Moon; Russell S Taichman; Catherine H Van Poznak; Gregory A Clines
Journal:  Neurosurgery       Date:  2018-12-01       Impact factor: 4.654

5.  Probing 3D Collective Cancer Invasion Using Double-Stranded Locked Nucleic Acid Biosensors.

Authors:  Zachary S Dean; Paul Elias; Nima Jamilpour; Urs Utzinger; Pak Kin Wong
Journal:  Anal Chem       Date:  2016-08-16       Impact factor: 6.986

6.  Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation.

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Journal:  J Biol Chem       Date:  2013-02-28       Impact factor: 5.157

7.  FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma.

Authors:  Matthew R Ramsey; Catherine Wilson; Benjamin Ory; S Michael Rothenberg; William Faquin; Alea A Mills; Leif W Ellisen
Journal:  J Clin Invest       Date:  2013-07-08       Impact factor: 14.808

Review 8.  Cell migration.

Authors:  Xavier Trepat; Zaozao Chen; Ken Jacobson
Journal:  Compr Physiol       Date:  2012-10       Impact factor: 9.090

Review 9.  Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin.

Authors:  Lindsay T McDonald; Amanda C LaRue
Journal:  Int J Clin Exp Pathol       Date:  2012-10-20

10.  The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos.

Authors:  Sophie M Morgani; Jie Su; Jennifer Nichols; Joan Massagué; Anna-Katerina Hadjantonakis
Journal:  Elife       Date:  2021-04-30       Impact factor: 8.140
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