Literature DB >> 19262101

Killing the messenger: The role of CXCR7 in regulating primordial germ cell migration.

Harsha Mahabaleshwar1, Bijan Boldajipour, Erez Raz.   

Abstract

Primordial Germ Cell (PGC) migration in zebrafish is guided by SDF-1a. Binding of this chemokine to its receptor CXCR4b activates downstream signalling cascades leading to cell polarization and directed migration towards the attractant source. Despite the detailed information available concerning the role of SDF-1 in guiding the PGCs to their targets, little was known regarding the molecular mechanisms controlling the distribution of SDF-1a within the tissue. We have recently shown that the activity of a second SDF-1/CXCL12 receptor, CXCR7 is crucial for proper migration of PGCs. Although CXCR4 and CXCR7 are structurally related and serve as receptors for the same ligand, they appear to serve very different functions during PGC migration. Here we discuss a model according to which CXCR4b translates the polarized distribution of SDF-1 into directed PGC migration, while CXCR7 acts as a high-affinity decoy receptor and facilitates the migration of PGCs by shaping the distribution of the chemokine in the environment.

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Year:  2008        PMID： 19262101      PMCID： PMC2634986          DOI： 10.4161/cam.2.2.6027

Source DB:  PubMed          Journal:  Cell Adh Migr        ISSN： 1933-6918            Impact factor:   3.405


  15 in total

1.  Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

Authors:  M Vicente-Manzanares; M Rey; D R Jones; D Sancho; M Mellado; J M Rodriguez-Frade; M A del Pozo; M Yáñez-Mó; A M de Ana; C Martínez-A; I Mérida; F Sánchez-Madrid
Journal:  J Immunol       Date:  1999-10-01       Impact factor: 5.422

2.  Guidance of primordial germ cell migration by the chemokine SDF-1.

Authors:  Maria Doitsidou; Michal Reichman-Fried; Jürg Stebler; Marion Köprunner; Julia Dörries; Dirk Meyer; Camila V Esguerra; TinChung Leung; Erez Raz
Journal:  Cell       Date:  2002-11-27       Impact factor: 41.582

3.  A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor.

Authors:  Holger Knaut; Christian Werz; Robert Geisler; Christiane Nüsslein-Volhard
Journal:  Nature       Date:  2002-12-18       Impact factor: 49.962

4.  The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.

Authors:  Karl Balabanian; Bernard Lagane; Simona Infantino; Ken Y C Chow; Julie Harriague; Barbara Moepps; Fernando Arenzana-Seisdedos; Marcus Thelen; Françoise Bachelerie
Journal:  J Biol Chem       Date:  2005-08-17       Impact factor: 5.157

Review 5.  Tuning inflammation and immunity by chemokine sequestration: decoys and more.

Authors:  Alberto Mantovani; Raffaella Bonecchi; Massimo Locati
Journal:  Nat Rev Immunol       Date:  2006-12       Impact factor: 53.106

6.  Migration of zebrafish primordial germ cells: a role for myosin contraction and cytoplasmic flow.

Authors:  Heiko Blaser; Michal Reichman-Fried; Irinka Castanon; Karin Dumstrei; Florence L Marlow; Koichi Kawakami; Lilianna Solnica-Krezel; Carl-Philipp Heisenberg; Erez Raz
Journal:  Dev Cell       Date:  2006-11       Impact factor: 12.270

7.  The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b.

Authors:  Guillaume Valentin; Petra Haas; Darren Gilmour
Journal:  Curr Biol       Date:  2007-06-19       Impact factor: 10.834

8.  Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.

Authors:  Frederic Sierro; Christine Biben; Laura Martínez-Muñoz; Mario Mellado; Richard M Ransohoff; Meizhang Li; Blanche Woehl; Helen Leung; Joanna Groom; Marcel Batten; Richard P Harvey; Carlos Martínez-A; Charles R Mackay; Fabienne Mackay
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-05       Impact factor: 11.205

9.  Control of receptor internalization, signaling level, and precise arrival at the target in guided cell migration.

Authors:  Sofia Minina; Michal Reichman-Fried; Erez Raz
Journal:  Curr Biol       Date:  2007-07-03       Impact factor: 10.834

10.  A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.

Authors:  Jennifer M Burns; Bretton C Summers; Yu Wang; Anita Melikian; Rob Berahovich; Zhenhua Miao; Mark E T Penfold; Mary Jean Sunshine; Dan R Littman; Calvin J Kuo; Kevin Wei; Brian E McMaster; Kim Wright; Maureen C Howard; Thomas J Schall
Journal:  J Exp Med       Date:  2006-08-28       Impact factor: 14.307
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  15 in total

1.  Endothelial expression of CXCR7 and the regulation of systemic CXCL12 levels.

Authors:  Robert D Berahovich; Brian A Zabel; Susanna Lewén; Matthew J Walters; Karen Ebsworth; Yu Wang; Juan C Jaen; Thomas J Schall
Journal:  Immunology       Date:  2014-01       Impact factor: 7.397

Review 2.  Homeostatic chemokine receptors and organ-specific metastasis.

Authors:  Albert Zlotnik; Amanda M Burkhardt; Bernhard Homey
Journal:  Nat Rev Immunol       Date:  2011-08-25       Impact factor: 53.106

3.  Anatomical structure, and expression of CCL4 and CCL13-like during the development of maxillary barbel in Paramisgurnus dabryanus.

Authors:  Kianann Tan; Ruijing Geng; Zhiqiang Wang; Han Liu; Weimin Wang
Journal:  Organogenesis       Date:  2019-07-06       Impact factor: 2.500

Review 4.  The blood-brain barrier, chemokines and multiple sclerosis.

Authors:  David W Holman; Robyn S Klein; Richard M Ransohoff
Journal:  Biochim Biophys Acta       Date:  2010-08-06

Review 5.  Mechanisms guiding primordial germ cell migration: strategies from different organisms.

Authors:  Brian E Richardson; Ruth Lehmann
Journal:  Nat Rev Mol Cell Biol       Date:  2010-01       Impact factor: 94.444

6.  Role of chemokine network in the development and progression of ovarian cancer: a potential novel pharmacological target.

Authors:  Federica Barbieri; Adriana Bajetto; Tullio Florio
Journal:  J Oncol       Date:  2009-12-14       Impact factor: 4.375

7.  Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development.

Authors:  Tao Zhou; Ning Li; Yulin Jin; Qifan Zeng; Wendy Prabowo; Yang Liu; Changxu Tian; Lisui Bao; Shikai Liu; Zihao Yuan; Qiang Fu; Sen Gao; Dongya Gao; Rex Dunham; Neil H Shubin; Zhanjiang Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2018-05-14       Impact factor: 11.205

8.  CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity.

Authors:  Lillian Cruz-Orengo; David W Holman; Denise Dorsey; Liang Zhou; Penglie Zhang; Melissa Wright; Erin E McCandless; Jigisha R Patel; Gary D Luker; Dan R Littman; John H Russell; Robyn S Klein
Journal:  J Exp Med       Date:  2011-02-07       Impact factor: 14.307

9.  Profiling of Cxcl12 receptors, Cxcr4 and Cxcr7 in murine testis development and a spermatogenic depletion model indicates a role for Cxcr7 in controlling Cxcl12 activity.

Authors:  Birgit Westernströer; Nicole Terwort; Jens Ehmcke; Joachim Wistuba; Stefan Schlatt; Nina Neuhaus
Journal:  PLoS One       Date:  2014-12-02       Impact factor: 3.240

10.  CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12.

Authors:  Rita de Cássia Carvalho Melo; Ana Leda Longhini; Carolina Louzão Bigarella; Mariana Ozello Baratti; Fabiola Traina; Patrícia Favaro; Paula de Melo Campos; Sara Teresinha Olalla Saad
Journal:  PLoS One       Date:  2014-01-31       Impact factor: 3.240
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