Literature DB >> 192620

Effect of experimental diabetes and glucagon on cAMP-dependent protein kinase in rat liver.

H E Weber, L A Menahan, S N Chaudhuri, J C Shipp.   

Abstract

Liver protein kinase was determined in the absence and presence of cAMP4. Experimental alloxan diabetes resulted in a decrease in total protein kinase (+cAMP) and an increase in the activity ratio (-cAMP) divided by (+cAMP) in liver. Insulin treatment of diabetic rats reversed the observed changes in protein kinase in liver. Glucagon administered in vivo to normal rats caused an increase in the activity ratio and a decrease in total protein kinase activity in liver. The changes are similar to those in diabetes. A decrease in the ratio of insulin to glucagon in diabetes may account for the changes in protein kinase observed.

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Year:  1977        PMID： 192620     DOI： 10.1007/bf00745144

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  23 in total

1.  Estimation of serum or plasma protein using qualitative Benedict reagent.

Authors:  Q Z HUSSAIN; N S SHAH; S N CHAUDHURI
Journal:  Clin Chim Acta       Date:  1961-05       Impact factor: 3.786

2.  Regulation of adenosine 3',5'-monophosphate-dependent protein kinase. I. Preliminary characterization of the adipose tissue enzyme in crude extracts.

Authors:  J D Corbin; T R Soderling; C R Park
Journal:  J Biol Chem       Date:  1973-03-10       Impact factor: 5.157

3.  A cyclic 3',5'-amp-stimulated protein kinase from cardiac muscle.

Authors:  M A Brostrom; E M Reimann; D A Walsh; E G Krebs
Journal:  Adv Enzyme Regul       Date:  1970

4.  Action of adenosine 3',5'-monophosphate-dependent histone kinase in vivo.

Authors:  T A Langan
Journal:  J Biol Chem       Date:  1969-10-25       Impact factor: 5.157

5.  A cyclic-3',5'-adenosine monophosphate dependent protein kinase from the adrenal cortex: comparison with a cyclic AMP binding protein.

Authors:  G N Gill; L D Garren
Journal:  Biochem Biophys Res Commun       Date:  1970-05-11       Impact factor: 3.575

6.  Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.

Authors:  L S Jefferson; J H Exton; R W Butcher; E W Sutherland; C R Park
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

7.  Adenosine 3', 5'-monophosphate and histone phosphorylation during enzyme induction by glucagon in rat liver.

Authors:  M Takeda; Y Oga
Journal:  J Biochem       Date:  1973-03       Impact factor: 3.387

8.  Protein kinase translocation as an early event in the hormonal control of uterine contraction.

Authors:  S G Korenman; R C Bhalla; B M Sanborn; R H Stevens
Journal:  Science       Date:  1974-02-01       Impact factor: 47.728

9.  Phosphorylation of liver histone following the administration of glucagon and insulin.

Authors:  T A Langan
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205

10.  Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle.

Authors:  C O Brostrom; J D Corbin; C A King; E G Krebs
Journal:  Proc Natl Acad Sci U S A       Date:  1971-10       Impact factor: 11.205
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  1 in total

1.  The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model.

Authors:  Rabia Johnson; Phiwayinkosi V Dludla; Christo J F Muller; Barbara Huisamen; M Faadiel Essop; Johan Louw
Journal:  Molecules       Date:  2017-01-31       Impact factor: 4.411
  1 in total

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