BACKGROUND AND OBJECTIVES: The Comprehensive Dialysis Study (CDS) aimed to understand factors contributing to physical, functional, and nutritional health status among patients starting dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A phone interview survey was conducted with patients from a geographically stratified national random sample of dialysis units, and quarterly serum samples were obtained for patients at a preidentified subset of units. The phone survey collected standardized measures of physical activity, employment and disability status, perceived health and well-being, and dietary intake. Serum samples were obtained to measure prealbumin, albumin, creatinine, normalized protein catabolic rate, and C-reactive protein. To comply with restrictions required under the Health Insurance Portability and Accountability Act (HIPAA), dialysis unit personnel could not participate in any research-related activities. RESULTS: Overall participation rate was 18.5%. One thousand six hundred forty-six patients affiliated with 295 dialysis units completed the phone survey; 361 patients affiliated with 68 dialysis units also completed a dietary intake survey, with 269 providing serum samples. Despite challenges in the design and implementation of CDS, the population was diverse and results should be generalizable. CONCLUSIONS: Constraints within the dialysis industry and HIPAA requirements render the assembly of nationally representative cohorts extremely difficult. Nevertheless, the CDS represents the largest cohort of incident dialysis patients containing detailed information on self-reported physical activity and dietary intake and is one of few cohorts simultaneously measuring laboratory proxies of nutrition and inflammatory status. Data from CDS can be used to inform the design of interventions addressing several conditions that affect longevity and health status in ESRD.
BACKGROUND AND OBJECTIVES: The Comprehensive Dialysis Study (CDS) aimed to understand factors contributing to physical, functional, and nutritional health status among patients starting dialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A phone interview survey was conducted with patients from a geographically stratified national random sample of dialysis units, and quarterly serum samples were obtained for patients at a preidentified subset of units. The phone survey collected standardized measures of physical activity, employment and disability status, perceived health and well-being, and dietary intake. Serum samples were obtained to measure prealbumin, albumin, creatinine, normalized protein catabolic rate, and C-reactive protein. To comply with restrictions required under the Health Insurance Portability and Accountability Act (HIPAA), dialysis unit personnel could not participate in any research-related activities. RESULTS: Overall participation rate was 18.5%. One thousand six hundred forty-six patients affiliated with 295 dialysis units completed the phone survey; 361 patients affiliated with 68 dialysis units also completed a dietary intake survey, with 269 providing serum samples. Despite challenges in the design and implementation of CDS, the population was diverse and results should be generalizable. CONCLUSIONS: Constraints within the dialysis industry and HIPAA requirements render the assembly of nationally representative cohorts extremely difficult. Nevertheless, the CDS represents the largest cohort of incident dialysis patients containing detailed information on self-reported physical activity and dietary intake and is one of few cohorts simultaneously measuring laboratory proxies of nutrition and inflammatory status. Data from CDS can be used to inform the design of interventions addressing several conditions that affect longevity and health status in ESRD.
Authors: Richard P Allen; Daniel Picchietti; Wayne A Hening; Claudia Trenkwalder; Arthur S Walters; Jacques Montplaisi Journal: Sleep Med Date: 2003-03 Impact factor: 3.492
Authors: Robert M Lindsay; Paul A Heidenheim; Gihad Nesrallah; Amit X Garg; Rita Suri Journal: Clin J Am Soc Nephrol Date: 2006-07-06 Impact factor: 8.237
Authors: Laura C Plantinga; Kirsten Johansen; Deidra C Crews; Vahakn B Shahinian; Bruce M Robinson; Rajiv Saran; Nilka Ríos Burrows; Desmond E Williams; Neil R Powe Journal: Am J Kidney Dis Date: 2010-10-30 Impact factor: 8.860
Authors: Mary Pipkin; Paul W Eggers; Brett Larive; Michael V Rocco; John B Stokes; Rita S Suri; Robert S Lockridge Journal: Clin J Am Soc Nephrol Date: 2010-06-24 Impact factor: 8.237
Authors: Michael V Rocco; Brett Larive; Paul W Eggers; Gerald J Beck; Glenn M Chertow; Nathan W Levin; Alan S Kliger Journal: Am J Kidney Dis Date: 2010-11-30 Impact factor: 8.860
Authors: Shuchi Anand; Glenn M Chertow; Kirsten L Johansen; Barbara Grimes; Manjula Kurella Tamura; Lorien S Dalrymple; George A Kaysen Journal: J Ren Nutr Date: 2011-01-15 Impact factor: 3.655
Authors: Kirsten L Johansen; Glenn M Chertow; Nancy G Kutner; Lorien S Dalrymple; Barbara A Grimes; George A Kaysen Journal: Kidney Int Date: 2010-09-01 Impact factor: 10.612
Authors: Cynthia Delgado; Stephanie Shieh; Barbara Grimes; Glenn M Chertow; Lorien S Dalrymple; George A Kaysen; John Kornak; Kirsten L Johansen Journal: Am J Nephrol Date: 2015-09-19 Impact factor: 3.754