| Literature DB >> 19261349 |
Simona Bevilacqua1, Marianna Gallo, Renato Franco, Antonio Rossi, Antonella De Luca, Gaetano Rocco, Gerardo Botti, Cesare Gridelli, Nicola Normanno.
Abstract
A 71-year-old patient with a pulmonary lesion was diagnosed with a low-grade neuroendocrine tumor following examination of a fine needle aspiration biopsy. Analysis of a peripheral blood sample with the CellSearch system revealed the presence of putative circulating tumor cells (CTC) that were positive for EpCAM and cytokeratin (CK) expression. Since EpCAM is not usually expressed in neuroendocrine tumors, we performed a biopsy of liver metastases. Morphological and immunophenotypical characterization revealed that the patient had an EpCAM and CK positive small-cell lung cancer (SCLC). By using the CellSearch apparatus, EpCAM/CK positive CTC were detected in peripheral blood samples from 3 out of 4 additional SCLC patients. This study is the first to demonstrate that CTC can be identified in SCLC patients by using the CellSearch system.Entities:
Mesh：
Year: 2009 PMID： 19261349 DOI： 10.1016/j.lungcan.2009.01.019
Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705