OBJECTIVES: QT interval prolongation is prevalent among patients with Takotsubo cardiomyopathy (TC), whereas torsades de pointes (TdP) has rarely been reported in these patients. We studied all peer-reviewed reports on TC-associated QT interval prolongation and all peer-reviewed reports on TC-associated TdP to characterize the clinical circumstances leading to TdP in patients with TC. METHODS: The literature search yielded 14 reports on TC-associated TdP and 26 reports on TC-associated QT interval prolongation. Overall, 15 patients with TC-associated TdP and 86 patients with TC-associated QT interval prolongation were reported. We systematically reviewed each report and recorded the risk factors for TdP as well as the clinical circumstances of TC. RESULTS: The prevalence of the male sex was higher among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (26.7% vs 5.8%; P = .01). There was a trend in the mean maximal corrected QT interval being longer among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (679.9 +/- 230.6 vs 555.9 +/- 63.8 milliseconds; P = .06). There were no differences between patients with TC-associated TdP and patients with TC-associated QT interval prolongation in mean age, maximal troponin levels, and lowest ejection fraction. Overall, 12 (80.0%) patients with TC-associated TdP had risk factors for TdP other than the female sex and systolic dysfunction, including suspicion of congenital long QT syndrome, bradycardia, hypokalemia, recent conversion from atrial fibrillation to sinus rhythm, and using QT prolonging agents. CONCLUSIONS: Men with TC-associated QT interval prolongation are at risk for TdP. Most patients with TC-associated TdP have risk factors for TdP other than the female sex and systolic dysfunction.
OBJECTIVES:QT interval prolongation is prevalent among patients with Takotsubo cardiomyopathy (TC), whereas torsades de pointes (TdP) has rarely been reported in these patients. We studied all peer-reviewed reports on TC-associated QT interval prolongation and all peer-reviewed reports on TC-associated TdP to characterize the clinical circumstances leading to TdP in patients with TC. METHODS: The literature search yielded 14 reports on TC-associated TdP and 26 reports on TC-associated QT interval prolongation. Overall, 15 patients with TC-associated TdP and 86 patients with TC-associated QT interval prolongation were reported. We systematically reviewed each report and recorded the risk factors for TdP as well as the clinical circumstances of TC. RESULTS: The prevalence of the male sex was higher among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (26.7% vs 5.8%; P = .01). There was a trend in the mean maximal corrected QT interval being longer among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (679.9 +/- 230.6 vs 555.9 +/- 63.8 milliseconds; P = .06). There were no differences between patients with TC-associated TdP and patients with TC-associated QT interval prolongation in mean age, maximal troponin levels, and lowest ejection fraction. Overall, 12 (80.0%) patients with TC-associated TdP had risk factors for TdP other than the female sex and systolic dysfunction, including suspicion of congenital long QT syndrome, bradycardia, hypokalemia, recent conversion from atrial fibrillation to sinus rhythm, and using QT prolonging agents. CONCLUSIONS:Men with TC-associated QT interval prolongation are at risk for TdP. Most patients with TC-associated TdP have risk factors for TdP other than the female sex and systolic dysfunction.
Authors: Ji Hun Ahn; Sang-Ho Park; Won Yong Shin; Se Whan Lee; Seung Jin Lee; Dong Kyu Jin; Han Min Lee; Jun Young Eun Journal: J Korean Med Sci Date: 2011-06-20 Impact factor: 2.153
Authors: Sebastiano Gili; Victoria L Cammann; Susanne A Schlossbauer; Ken Kato; Fabrizio D'Ascenzo; Davide Di Vece; Stjepan Jurisic; Jozef Micek; Slayman Obeid; Beatrice Bacchi; Konrad A Szawan; Flurina Famos; Annahita Sarcon; Rena Levinson; Katharina J Ding; Burkhardt Seifert; Olivia Lenoir; Eduardo Bossone; Rodolfo Citro; Jennifer Franke; L Christian Napp; Milosz Jaguszewski; Michel Noutsias; Thomas Münzel; Maike Knorr; Susanne Heiner; Hugo A Katus; Christof Burgdorf; Heribert Schunkert; Holger Thiele; Johann Bauersachs; Carsten Tschöpe; Burkert M Pieske; Lawrence Rajan; Guido Michels; Roman Pfister; Alessandro Cuneo; Claudius Jacobshagen; Gerd Hasenfuß; Mahir Karakas; Wolfgang Koenig; Wolfgang Rottbauer; Samir M Said; Ruediger C Braun-Dullaeus; Adrian Banning; Florim Cuculi; Richard Kobza; Thomas A Fischer; Tuija Vasankari; K E Juhani Airaksinen; Grzegorz Opolski; Rafal Dworakowski; Philip MacCarthy; Christoph Kaiser; Stefan Osswald; Leonarda Galiuto; Filippo Crea; Wolfgang Dichtl; Klaus Empen; Stephan B Felix; Clément Delmas; Olivier Lairez; Ibrahim El-Battrawy; Ibrahim Akin; Martin Borggrefe; Ekaterina Gilyarova; Alexandra Shilova; Mikhail Gilyarov; John D Horowitz; Martin Kozel; Petr Tousek; Petr Widimský; David E Winchester; Christian Ukena; Fiorenzo Gaita; Carlo Di Mario; Manfred B Wischnewsky; Jeroen J Bax; Abhiram Prasad; Michael Böhm; Frank Ruschitzka; Thomas F Lüscher; Jelena R Ghadri; Christian Templin Journal: Eur Heart J Date: 2019-07-01 Impact factor: 29.983