| Literature DB >> 19259616 |
Paola Gaviani1, A Silvani, E Corsini, A Erbetta, A Salmaggi.
Abstract
Neoplastic meningitis from breast cancer often leads to a progressive neurologic deterioration followed by fatal outcome. The therapy is based on the administration of high dose systemic chemotherapy with drugs able to pass through the blood-brain barrier, such as methotrexate (MTX) and cytarabine, cranial or craniospinal irradiation, and intrathecal (IT) administration of MTX and/or cytarabine. However, these approaches only have modest efficacy and are associated with side effects for the patients. A depot formulation of liposomal cytarabine (DepoCyte) has proven to be useful in clinical trials. We describe the case of a woman with a diagnosis of leptomeningeal carcinomatosis from breast carcinoma who presented cerebrospinal fluid normalization and prolonged complete MRI response to intrathecal chemotherapy with liposomal cytarabine (DepoCyte).Entities:
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Year: 2009 PMID： 19259616 DOI： 10.1007/s10072-009-0044-8
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307