Literature DB >> 19258923

Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

Christine L E Siezen1, Louis Bont, Hennie M Hodemaekers, Marieke J Ermers, Gerda Doornbos, Ruben Van't Slot, Ciska Wijmenga, Hans C van Houwelingen, Jan L L Kimpen, Tjeerd G Kimman, Barbara Hoebee, Riny Janssen.   

Abstract

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.

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Year:  2009        PMID： 19258923     DOI： 10.1097/INF.0b013e31818e2aa9

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   2.129


  31 in total

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