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Literature DB >> 19258399

OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness.

Spyros I Papamichos¹, Vassiliki Kotoula, Basil C Tarlatzis, Theodoros Agorastos, Konstantinos Papazisis, Alexandros F Lambropoulos.

Abstract

A novel OCT4 alternative spliced variant (OCT 4B1) is deduced to be the isoform present in 59 hESC lines characterised by the International Stem Cell Initiative (ISCI) rather than OCT4A as previously assumed. The new variant may be a more reliable marker of stemness than OCT4A and studies are needed to test this.

Entities: Gene

Mesh：

Substances：

Year: 2009 PMID： 19258399 DOI： 10.1093/molehr/gap018

Source DB: PubMed Journal: Mol Hum Reprod ISSN： 1360-9947 Impact factor: 4.025

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Cited

13 in total

1. A comparative study on nonviral genetic modifications in cord blood and bone marrow mesenchymal stem cells.

Authors: Behnaz Bakhshandeh; Masoud Soleimani; Maryam Hafizi; Nasser Ghaemi
Journal: Cytotechnology Date: 2012-02-11 Impact factor: 2.058

Review 2. Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology.

Authors: Xia Wang; Jianwu Dai
Journal: Stem Cells Date: 2010-05 Impact factor: 6.277

3. Altered expression of apoptotic genes in response to OCT4B1 suppression in human tumor cell lines.

Authors: Mohammad Reza Mirzaei; Ali Najafi; Mohammad Kazemi Arababadi; Malek Hosein Asadi; Seyed Javad Mowla
Journal: Tumour Biol Date: 2014-07-11

4. OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells.

Authors: Lu Meng; Hongyu Hu; Huifang Zhi; Yue Liu; Fangyu Shi; Laiguang Zhang; Yanjun Zhou; Aixing Lin
Journal: Oncol Lett Date: 2018-05-02 Impact factor: 2.967

5. Alternative splicing in self-renewal of embryonic stem cells.

Authors: Clara Y Cheong; Thomas Lufkin
Journal: Stem Cells Int Date: 2011-06-09 Impact factor: 5.443

6. Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.

Authors: M A Rijlaarsdam; H A D M van Herk; A J M Gillis; H Stoop; G Jenster; J Martens; G J L H van Leenders; W Dinjens; A M Hoogland; M Timmermans; L H J Looijenga
Journal: Br J Cancer Date: 2011-08-16 Impact factor: 7.640

OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness.

1. A comparative study on nonviral genetic modifications in cord blood and bone marrow mesenchymal stem cells.

Review 2. Concise review: isoforms of OCT4 contribute to the confusing diversity in stem cell biology.

3. Altered expression of apoptotic genes in response to OCT4B1 suppression in human tumor cell lines.

4. OCT4B regulates p53 and p16 pathway genes to prevent apoptosis of breast cancer cells.

5. Alternative splicing in self-renewal of embryonic stem cells.

6. Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.

7. The differential expression of OCT4 isoforms in cervical carcinoma.

8. Differential Expression of OCT4 Pseudogenes in Pluripotent and Tumor Cell Lines.

9. Oct4B, CD90, and CD73 are upregulated in bladder tissue following electro-resection of the bladder.

10. OCT4B1 Regulates the Cellular Stress Response of Human Dental Pulp Cells with Inflammation.