Literature DB >> 1925598

Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.

T R Sutter1, K Guzman, K M Dold, W F Greenlee.   

Abstract

Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1 beta. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.

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Year:  1991        PMID： 1925598     DOI： 10.1126/science.1925598

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  49 in total

1.  2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation.

Authors:  Carrie Hayes Sutter; Sridevi Bodreddigari; Christina Campion; Ryan S Wible; Thomas R Sutter
Journal:  Toxicol Sci       Date:  2011-08-11       Impact factor: 4.849

2.  Immunotoxic effects of exposure of rats to xenobiotics via maternal lactation. Part I 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  J S Badesha; G Maliji; B Flaks
Journal:  Int J Exp Pathol       Date:  1995-12       Impact factor: 1.925

3.  Mutations in CYP1B1, the gene for cytochrome P4501B1, are the predominant cause of primary congenital glaucoma in Saudi Arabia.

Authors:  B A Bejjani; R A Lewis; K F Tomey; K L Anderson; D K Dueker; M Jabak; W F Astle; B Otterud; M Leppert; J R Lupski
Journal:  Am J Hum Genet       Date:  1998-02       Impact factor: 11.025

Review 4.  The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells.

Authors:  Eszter Baricza; Viola Tamási; Nikolett Marton; Edit I Buzás; György Nagy
Journal:  Cell Mol Life Sci       Date:  2015-10-28       Impact factor: 9.261

5.  p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells.

Authors:  S K Kolluri; C Weiss; A Koff; M Göttlicher
Journal:  Genes Dev       Date:  1999-07-01       Impact factor: 11.361

Review 6.  A new cross-talk between the aryl hydrocarbon receptor and RelB, a member of the NF-kappaB family.

Authors:  Christoph F A Vogel; Fumio Matsumura
Journal:  Biochem Pharmacol       Date:  2008-10-08       Impact factor: 5.858

7.  Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7.

Authors:  C Vogel; J Abel
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

8.  RelB, a new partner of aryl hydrocarbon receptor-mediated transcription.

Authors:  Christoph F A Vogel; Eric Sciullo; Wen Li; Pat Wong; Gwendal Lazennec; Fumio Matsumura
Journal:  Mol Endocrinol       Date:  2007-09-06

9.  2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation.

Authors:  Lawrence H Kennedy; Carrie Hayes Sutter; Sandra Leon Carrion; Quynh T Tran; Sridevi Bodreddigari; Elizabeth Kensicki; Robert P Mohney; Thomas R Sutter
Journal:  Toxicol Sci       Date:  2012-11-14       Impact factor: 4.849

10.  Polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. Effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on peripheral lymphocyte subpopulations of a non-human primate (Callithrix jacchus).

Authors:  R Neubert; G Golor; R Stahlmann; H Helge; D Neubert
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153
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