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Literature DB >> 19255786

Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challenges.

Rashad Abdul-Ghani¹, Naguiba Loutfy, Amel el-Sahn, Azza Hassan.

Abstract

Schistosomiasis still represents a major health problem in many tropical and subtropical countries despite continuing control efforts. Due to the unavailability of a vaccine that is practically applicable to humans, the use of chemotherapy is the mainstay of schistosomiasis-associated morbidity control. This paper attempts to review the antischistosomal drugs currently used in the treatment of intestinal schistosomiasis caused by Schistosoma mansoni. Their antischistosomal properties, advantages, and disadvantages as well as issues regarding the evidence for drug resistance and combination studies are reviewed in a simple manner. The recent trends towards the identification of specific chemotherapeutic targets for the treatment of schistosomes are also discussed briefly.

Entities: Disease Species

Mesh：

Substances：
Anthelmintics

Year: 2009 PMID： 19255786 DOI： 10.1007/s00436-009-1371-7

Source DB: PubMed Journal: Parasitol Res ISSN： 0932-0113 Impact factor: 2.289

102 in total

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22 in total

1. In vitro efficacy of the essential oil of Piper cubeba L. (Piperaceae) against Schistosoma mansoni.

Authors: Lizandra G Magalhães; Julia M de Souza; Kamila A L Wakabayashi; Rosangela da S Laurentiz; Adriana H C Vinhólis; Karen C S Rezende; Guilherme V Simaro; Jairo K Bastos; Vanderlei Rodrigues; Viviane R Esperandim; Daniele S Ferreira; Antônio E M Crotti; Wilson R Cunha; Márcio L A e Silva
Journal: Parasitol Res Date: 2011-10-19 Impact factor: 2.289

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Authors: A S A Pereira; N L Cavalcanti; G A F Nascimento; J L G Nascimento-Silva; R J R Padilha; L F W Viegas; L C Alves; J L Lima-Filho; M E C Chaves
Journal: Parasitol Res Date: 2012-12-20 Impact factor: 2.289

3. Physicochemical properties and anti-opisthorchosis effect of mechanochemically synthesized supramolecular complexes of Albendazole with the polysaccharide Arabinogalactan from Larix sibirica and Larix gmelinii.

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Journal: Dokl Biol Sci Date: 2014-07-02

4. Effect of Mirazid in Schistosoma japonicum-infected mice: parasitological and pathological assessment.

Authors: Mohamed A El-Malky; Shao-Hong Lu; Samar N El-Beshbishi; Niveen S Saudy; Nobu Ohta
Journal: Parasitol Res Date: 2012-10-03 Impact factor: 2.289

5. Effectiveness of synthetic trioxolane OZ78 against Schistosoma japonicum in mice and rabbits.

Authors: Shu-Hua Xiao; Jian Xue; Jing-Yan Mei; Pei-Ying Jiao
Journal: Parasitol Res Date: 2011-12-27 Impact factor: 2.289

6. Artemether shows promising female schistosomicidal and ovicidal effects on the Egyptian strain of Schistosoma mansoni after maturity of infection.

Authors: Rashad Abdul-Ghani; Naguiba Loutfy; Manal Sheta; Azza Hassan
Journal: Parasitol Res Date: 2010-11-25 Impact factor: 2.289

7. A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility.

Authors: Michael J Smout; Andrew C Kotze; James S McCarthy; Alex Loukas
Journal: PLoS Negl Trop Dis Date: 2010-11-16