OBJECTIVE AND DESIGN: This study investigated if feG-COOH would decrease allergen-induced airway inflammation. MATERIALS OR SUBJECTS: Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype. TREATMENT: Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design. METHODS: Bronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via inflammatory cell number and type; IL-4, IFN-gamma and nitric oxide metabolite concentrations. A paired t test was used to compare parameters with a P < 0.05 considered significant. RESULTS: The BALF eosinophil percentage was significantly lower in asthmatic cats treated with feG compared with placebo (placebo, 35.3 +/- 12.2%; feG, 22.4 +/- 8.6%; P = 0.002). Treatment with feG did not result in a significant change in any other parameter measured. CONCLUSIONS: These data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma.
OBJECTIVE AND DESIGN: This study investigated if feG-COOH would decrease allergen-induced airway inflammation. MATERIALS OR SUBJECTS: Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype. TREATMENT: Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design. METHODS: Bronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via inflammatory cell number and type; IL-4, IFN-gamma and nitric oxide metabolite concentrations. A paired t test was used to compare parameters with a P < 0.05 considered significant. RESULTS: The BALF eosinophil percentage was significantly lower in asthmatic cats treated with feG compared with placebo (placebo, 35.3 +/- 12.2%; feG, 22.4 +/- 8.6%; P = 0.002). Treatment with feG did not result in a significant change in any other parameter measured. CONCLUSIONS: These data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma.
Authors: Carol R Reinero; Leah A Cohn; Cherlene Delgado; Christine M Spinka; Elizabeth K Schooley; Amy E DeClue Journal: Vet Immunol Immunopathol Date: 2007-10-02 Impact factor: 2.046
Authors: Chris D St Laurent; Katherine E St Laurent; Ron D Mathison; A Dean Befus Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-01-28 Impact factor: 3.619