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Literature DB >> 19255569

Breast cancer quality control.

Abstract

Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19255569 DOI： 10.1038/ncb0309-239

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

Review 1. CHIP: a link between the chaperone and proteasome systems.

Authors: Holly McDonough; Cam Patterson
Journal: Cell Stress Chaperones Date: 2003 Impact factor: 3.667

2. CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

Authors: Hong Xin; Xialian Xu; Linyu Li; Hongxiu Ning; Yu Rong; Yu Shang; Yinyin Wang; Xin-Yuan Fu; Zhijie Chang
Journal: J Biol Chem Date: 2005-03-21 Impact factor: 5.157

3. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.

Authors: Jin-Na Min; Ryan A Whaley; Norman E Sharpless; Pamela Lockyer; Andrea L Portbury; Cam Patterson
Journal: Mol Cell Biol Date: 2008-04-14 Impact factor: 4.272

4. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

Authors: Chad A Dickey; Mei Yue; Wen-Lang Lin; Dennis W Dickson; Judith H Dunmore; Wing C Lee; Cynthia Zehr; Gemma West; Songsong Cao; Amber M K Clark; Guy A Caldwell; Kim A Caldwell; Christopher Eckman; Cam Patterson; Michael Hutton; Leonard Petrucelli
Journal: J Neurosci Date: 2006-06-28 Impact factor: 6.167

2. E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells.

Authors: Jingjing Xu; Huan Wang; Wenjing Li; Kaili Liu; Tingli Zhang; Zhijie He; Feng Guo
Journal: Clin Exp Med Date: 2019-12-16 Impact factor: 3.984

Review 3. Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer.

Authors: Ioannis A Voutsadakis
Journal: Tumour Biol Date: 2012-03-06

3 in total

Breast cancer quality control.

Review 1. CHIP: a link between the chaperone and proteasome systems.

2. CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation.

3. CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.

4. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

5. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

Review 6. Hsp90 inhibitors as novel cancer chemotherapeutic agents.

7. Ligand-dependent switching of ubiquitin-proteasome pathways for estrogen receptor.

8. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock.

9. CHIP activates HSF1 and confers protection against apoptosis and cellular stress.

10. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.

1. New insights into TRAP1 pathway.

2. E3 ubiquitin ligase CHIP attenuates cellular proliferation and invasion abilities in triple-negative breast cancer cells.

Review 3. Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer.