Literature DB >> 19254975

Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children younger than 5 years of age.

Johannes Forster1, Alfredo Guarino, Nathalie Parez, Fernando Moraga, Enriqueta Román, Olivier Mory, Alberto E Tozzi, Ana López de Aguileta, Ulrich Wahn, Clive Graham, Reinhard Berner, Titus Ninan, Celia Barberousse, Nadia Meyer, Montse Soriano-Gabarró.   

Abstract

OBJECTIVES: Rotavirus is the leading cause of acute gastroenteritis requiring hospitalization in young children. Data on the burden of rotavirus gastroenteritis are needed to guide recommendations for rotavirus vaccine use. This study was undertaken to estimate the burden of rotavirus gastroenteritis in European children <5 years of age.
METHODS: This prospective, study was conducted in 12 hospitals in France, Germany, Italy, Spain, and the United Kingdom. A sample of all children aged <5 years presenting to emergency departments or hospitalized because of community-acquired acute gastroenteritis was enrolled for parental interview and stool collection. Acute gastroenteritis was defined as diarrhea (>/=3 loose stools per 24 hours) for <14 days. Rotavirus was detected by enzyme-linked immunosorbent assay and typed by reverse-transcriptase polymerase chain reaction.
RESULTS: Between February 2005 and August 2006, 3734 children with community-acquired acute gastroenteritis were recruited and retained for analysis (55.9% via the emergency department, 41.8% hospitalized). Of the 2928 community-acquired acute gastroenteritis cases for which stool samples were available, 43.4% were rotavirus-positive by enzyme-linked immunosorbent assay (32.8% emergency department, 56.2% hospitalized). Of these rotavirus gastroenteritis cases 80.9% occurred in children aged <2 years and 15.9% among infants aged <6 months. Acute gastroenteritis was more severe in rotavirus-positive subjects (Vesikari score >/= 11 in 53.3% compared with 31.0% of rotavirus-negative subjects). All 1271 rotavirus-positive strains were genotyped (G1P[8]: 40.3%; G9P[8]: 31.2%; G4P[8]: 13.5%; G3P[8]: 7.1%).
CONCLUSIONS: Rotavirus gastroenteritis places high demands on European health care systems, accounting for 56.2% of hospitalizations and 32.8% of emergency department visits because of community-acquired acute gastroenteritis in children aged <5 years. Most community-acquired rotavirus gastroenteritis occurs in children aged <2 years, and a high proportion occurs in infants aged <6 months. Cases were also observed among very young infants <2 months of age. Rotavirus vaccination is expected to have a major impact in reducing morbidity and the pressure on hospital services in Europe.

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Year:  2009        PMID: 19254975     DOI: 10.1542/peds.2008-2088

Source DB:  PubMed          Journal:  Pediatrics        ISSN: 0031-4005            Impact factor:   7.124


  62 in total

1.  Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis.

Authors:  Petra Kaiser; Michael Borte; Klaus-Peter Zimmer; Hans-Iko Huppertz
Journal:  Eur J Pediatr       Date:  2011-08-11       Impact factor: 3.183

2.  Molecular Epidemiology of Rotavirus Strains in Under Five Children.

Authors:  Yunus Bulut; Gülgün Yenişehirli; Rıza Durmaz
Journal:  Indian J Pediatr       Date:  2017-11-29       Impact factor: 1.967

Review 3.  Burden of rotavirus gastroenteritis in the pediatric population in Central and Eastern Europe: serotype distribution and burden of illness.

Authors:  Isla Ogilvie; Hanane Khoury; Antoine C El Khoury; Mireille M Goetghebeur
Journal:  Hum Vaccin       Date:  2011-05-01

4.  Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain.

Authors:  Olga Redondo; Rosa Cano; Lorena Simón
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

Review 5.  Rotavirus infections and vaccines: burden of illness and potential impact of vaccination.

Authors:  Keith Grimwood; Stephen B Lambert; Richard J Milne
Journal:  Paediatr Drugs       Date:  2010-08-01       Impact factor: 3.022

6.  Rotavirus vaccines in Israel: Uptake and impact.

Authors:  Khitam Muhsen; Daniel Cohen
Journal:  Hum Vaccin Immunother       Date:  2017-03-10       Impact factor: 3.452

7.  Rotavirus gastroenteritis in children less than five years of age in primary care settings in Bulgaria: an observational study.

Authors:  Mayda Tiholova; Kusuma Gopala; Magda Berberova; Margarita Strokova-Stoilova; Monica Tafalla
Journal:  Germs       Date:  2016-09-01

8.  Unexpectedly high burden of rotavirus gastroenteritis in very young infants.

Authors:  H Fred Clark; Amy E Marcello; Diane Lawley; Megan Reilly; Mark J DiNubile
Journal:  BMC Pediatr       Date:  2010-06-11       Impact factor: 2.125

9.  Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis in children below five years of age in Romania.

Authors:  Ioana Alina Anca; Florentina Ligia Furtunescu; Doina Pleşca; Adrian Streinu-Cercel; Sorin Rugină; Katsiaryna Holl
Journal:  Germs       Date:  2014-06-02

10.  Healthcare-associated viral gastroenteritis among children in a large pediatric hospital, United Kingdom.

Authors:  Nigel A Cunliffe; J Angela Booth; Claire Elliot; Sharon J Lowe; Will Sopwith; Nick Kitchin; Osamu Nakagomi; Toyoko Nakagomi; C Anthony Hart; Martyn Regan
Journal:  Emerg Infect Dis       Date:  2010-01       Impact factor: 6.883

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