Literature DB >> 19254761

Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology.

Lisa Y Pang1, David J Argyle.   

Abstract

The recently described cancer stem cell theory opens up many new challenges and opportunities to identify targets for therapeutic intervention. However, the majority of cancer related therapeutic studies rely upon rodent models of human cancer that rarely translate into clinical success in human patients. Naturally occurring cancers in dogs, cats and humans share biological features, including molecular targets, telomerase biology and tumour genetics. Studying cancer stem cell biology and telomere/telomerase dynamics in the cancer bearing pet population may offer the opportunity to develop a greater understanding of cancer biology in the natural setting and evaluate the development of novel therapies targeted at these systems.

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Year:  2009        PMID： 19254761     DOI： 10.1016/j.bbadis.2009.02.010

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  23 in total

1.  A vaccine targeting telomerase enhances survival of dogs affected by B-cell lymphoma.

Authors:  Daniela Peruzzi; Alessandra Gavazza; Giuseppe Mesiti; George Lubas; Elisa Scarselli; Antonella Conforti; Claus Bendtsen; Gennaro Ciliberto; Nicola La Monica; Luigi Aurisicchio
Journal:  Mol Ther       Date:  2010-06-08       Impact factor: 11.454

Review 2.  Oncogenic role and therapeutic target of leptin signaling in breast cancer and cancer stem cells.

Authors:  Shanchun Guo; Mingli Liu; Guangdi Wang; Marta Torroella-Kouri; Ruben R Gonzalez-Perez
Journal:  Biochim Biophys Acta       Date:  2012-01-24

3.  Distinct prognostic values of ALDH1 isoenzymes in breast cancer.

Authors:  Shaokun Wu; Weiping Xue; Xiaobo Huang; Xiaoli Yu; Ming Luo; Ying Huang; Yimin Liu; Zhuofei Bi; Xingsheng Qiu; Shoumin Bai
Journal:  Tumour Biol       Date:  2015-01-13

4.  Comparison of cancer stem cell antigen expression by tumor cell lines and by tumor biopsies from dogs with melanoma and osteosarcoma.

Authors:  Amanda M Guth; Mike Deogracias; Steven W Dow
Journal:  Vet Immunol Immunopathol       Date:  2014-07-24       Impact factor: 2.046

Review 5.  Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.

Authors:  Weiqiang Zhou; Shanchun Guo; Mingli Liu; Matthew E Burow; Guangdi Wang
Journal:  Curr Med Chem       Date:  2019       Impact factor: 4.530

6.  Peripheral blood biomarkers of solid tumor angiogenesis in dogs: a polychromatic flow cytometry pilot study.

Authors:  R Timothy Bentley; Julie A Mund; Karen E Pollok; Michael O Childress; Jamie Case
Journal:  Vet J       Date:  2012-10-12       Impact factor: 2.688

Review 7.  Leptin-cytokine crosstalk in breast cancer.

Authors:  Gale Newman; Ruben Rene Gonzalez-Perez
Journal:  Mol Cell Endocrinol       Date:  2013-04-04       Impact factor: 4.102

Review 8.  Oncogenic roles and drug target of CXCR4/CXCL12 axis in lung cancer and cancer stem cell.

Authors:  Zhidong Wang; Jian Sun; Yeqian Feng; Xiaocai Tian; Bin Wang; Yong Zhou
Journal:  Tumour Biol       Date:  2016-04-14

Review 9.  The Comparative Oncology Trials Consortium: using spontaneously occurring cancers in dogs to inform the cancer drug development pathway.

Authors:  Ira Gordon; Melissa Paoloni; Christina Mazcko; Chand Khanna
Journal:  PLoS Med       Date:  2009-10-13       Impact factor: 11.069

10.  Early maternal separation is not associated with changes in telomere length in domestic kittens (Felis catus).

Authors:  Mikel Delgado; C A Tony Buffington; Melissa Bain; Dana L Smith; Karen Vernau
Journal:  PeerJ       Date:  2021-06-01       Impact factor: 2.984
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