OBJECTIVE: To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD). METHODS: This paper describes the project design, demographics, clinical outcomes, and predictors at 6 months to 1 year of follow-up of the first 53 recruited subjects with first-episode mania from the Systematic Treatment Optimization Program for Early Mania. RESULTS: Survival analysis for recurrence of mood episodes showed that 46.7% of patients survived without a mood episode during 1-year of follow-up, and the mean time-to-mood event was 7.9 months. Earlier age of onset was the only variable that significantly predicted recurrence of mood episodes. When examined separately, the survival rates were 76% for a manic episode and 58.7% for a depressive episode. CONCLUSION: These results suggest that recurrences are common after the first manic episode with more than one-half of the patients experiencing a mood event within 12 months. Aggressive treatment strategies aimed at preventing depressive episodes are needed in the management of early course BD.
OBJECTIVE: To describe clinical characteristics, course, and outcome during a 1-year period after the first manic episode in patients with bipolar disorder (BD). METHODS: This paper describes the project design, demographics, clinical outcomes, and predictors at 6 months to 1 year of follow-up of the first 53 recruited subjects with first-episode mania from the Systematic Treatment Optimization Program for Early Mania. RESULTS: Survival analysis for recurrence of mood episodes showed that 46.7% of patients survived without a mood episode during 1-year of follow-up, and the mean time-to-mood event was 7.9 months. Earlier age of onset was the only variable that significantly predicted recurrence of mood episodes. When examined separately, the survival rates were 76% for a manic episode and 58.7% for a depressive episode. CONCLUSION: These results suggest that recurrences are common after the first manic episode with more than one-half of the patients experiencing a mood event within 12 months. Aggressive treatment strategies aimed at preventing depressive episodes are needed in the management of early course BD.
Authors: Xavier Estrada-Prat; Anna R Van Meter; Ester Camprodon-Rosanas; Santiago Batlle-Vila; Benjamin I Goldstein; Boris Birmaher Journal: Bipolar Disord Date: 2019-05-15 Impact factor: 6.744
Authors: Leonardo E Silveira; Jan-Marie Kozicky; Kesavan Muralidharan; Joana Bücker; Ivan J Torres; David J Bond; Flavio Kapczinski; Marcia Kauer-Sant'Anna; Raymond W Lam; Lakshmi N Yatham Journal: Can J Psychiatry Date: 2014-12 Impact factor: 4.356
Authors: Robert L Findling; Vivian Kafantaris; Mani Pavuluri; Nora K McNamara; Jean A Frazier; Linmarie Sikich; Robert Kowatch; Brieana M Rowles; Traci E Clemons; Perdita Taylor-Zapata Journal: J Child Adolesc Psychopharmacol Date: 2013-03 Impact factor: 2.576
Authors: Bernardo Dell'Osso; Saloni Shah; Dennis Do; Laura D Yuen; Farnaz Hooshmand; Po W Wang; Shefali Miller; Terence A Ketter Journal: Int J Bipolar Disord Date: 2017-01-25