Literature DB >> 1925308

Gastritis induced by Helicobacter pylori in gnotobiotic piglets.

S Krakowka1, K A Eaton, D M Rings, D R Morgan.   

Abstract

Helicobacter pylori has recently been recognized as a gastric pathogen in humans. Experimental oral inoculation of gnotobiotic piglets with this organism results in gastritis that exhibits many features of the corresponding disease in humans. In piglets the organism is restricted to the gastric microenvironment and persists in that location despite prompt humoral and cellular responses to antigens of H. pylori. The gnotobiotic piglet model is useful for delineation of the role of suspected bacterial virulence factors (i.e., motility and urease production) in gastric colonization and for preclinical determination of the efficacy of various antimicrobial substances.

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Year:  1991        PMID： 1925308     DOI： 10.1093/clinids/13.supplement_8.s681

Source DB:  PubMed          Journal:  Rev Infect Dis        ISSN： 0162-0886


  7 in total

1.  Experimental infection of pigs with 'Candidatus Helicobacter suis'.

Authors:  A Hellemans; K Chiers; A Decostere; M De Bock; F Haesebrouck; R Ducatelle
Journal:  Vet Res Commun       Date:  2007-05       Impact factor: 2.459

2.  Identification of novel Helicobacter species in pig stomachs by PCR and partial sequencing.

Authors:  Y K Choi; J H Han; H S Joo
Journal:  J Clin Microbiol       Date:  2001-09       Impact factor: 5.948

3.  Animal models of Helicobacter-induced disease: methods to successfully infect the mouse.

Authors:  Nancy S Taylor; James G Fox
Journal:  Methods Mol Biol       Date:  2012

4.  Molecular characterization of a conserved 20-kilodalton membrane-associated lipoprotein antigen of Helicobacter pylori.

Authors:  M Kostrzynska; P W O'Toole; D E Taylor; T J Trust
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

5.  Helicobacter pylori interacts with the human single-domain trefoil protein TFF1.

Authors:  Marguerite Clyne; Paul Dillon; Stephen Daly; Richard O'Kennedy; Felicity E B May; Bruce R Westley; Brendan Drumm
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

6.  Generation of antibody- and B cell-deficient pigs by targeted disruption of the J-region gene segment of the heavy chain locus.

Authors:  M Mendicino; J Ramsoondar; C Phelps; T Vaught; S Ball; T LeRoith; J Monahan; S Chen; A Dandro; J Boone; P Jobst; A Vance; N Wertz; Z Bergman; X-Z Sun; I Polejaeva; J Butler; Y Dai; D Ayares; K Wells
Journal:  Transgenic Res       Date:  2010-09-26       Impact factor: 2.788

7.  Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.

Authors:  Nicole Tegtmeyer; Francisco Rivas Traverso; Manfred Rohde; Omar A Oyarzabal; Norbert Lehn; Wulf Schneider-Brachert; Richard L Ferrero; James G Fox; Douglas E Berg; Steffen Backert
Journal:  PLoS One       Date:  2013-08-05       Impact factor: 3.240
  7 in total

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