Literature DB >> 19252303

Kinetic characterization of sulfasalazine transport by human ATP-binding cassette G2.

Márton Jani1, Pál Szabó, Emese Kis, Eva Molnár, Hristos Glavinas, Péter Krajcsi.   

Abstract

The pharmacokinetics of sulfasalazine, an anti-inflammatory drug is influenced by ATP-binding cassette G2 (ABCG2) (breast cancer resistance protein (BCRP), mitoxantrone resistance protein (MXR)) both in vitro and clinically. Due to its low passive permeability, the intracellular concentration of sulfasalazine is dependent on uptake transporters, rendering the characterization of transporter specific interactions in cell based experimental systems difficult. Applying membrane assays a detailed kinetic analysis of sulfasalazine ABCG2 interaction was conducted and Km values of 0.70 +/- 0.03 microM and 0.66 +/- 0.08 microM were obtained at pH 7.0 and pH 5.5, respectively.

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Year:  2009        PMID： 19252303     DOI： 10.1248/bpb.32.497

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  12 in total

1.  Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.

Authors:  Hiroyuki Kusuhara; Hidetoshi Furuie; Akihiro Inano; Akihiro Sunagawa; Saiko Yamada; Chunyong Wu; Shinya Fukizawa; Nozomi Morimoto; Ichiro Ieiri; Mariko Morishita; Kiminobu Sumita; Hiroshi Mayahara; Takuya Fujita; Kazuya Maeda; Yuichi Sugiyama
Journal:  Br J Pharmacol       Date:  2012-07       Impact factor: 8.739

2.  Predicting efflux ratios and blood-brain barrier penetration from chemical structure: combining passive permeability with active efflux by P-glycoprotein.

Authors:  Elena Dolghih; Matthew P Jacobson
Journal:  ACS Chem Neurosci       Date:  2012-12-11       Impact factor: 4.418

Review 3.  Structure and function of the human breast cancer resistance protein (BCRP/ABCG2).

Authors:  Zhanglin Ni; Zsolt Bikadi; Mark F Rosenberg; Qingcheng Mao
Journal:  Curr Drug Metab       Date:  2010-09       Impact factor: 3.731

4.  Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.

Authors:  Tsuyoshi Karibe; Rie Hagihara-Nakagomi; Koji Abe; Tomoki Imaoka; Tsuyoshi Mikkaichi; Satoru Yasuda; Masakazu Hirouchi; Nobuaki Watanabe; Noriko Okudaira; Takashi Izumi
Journal:  Pharm Res       Date:  2014-11-08       Impact factor: 4.200

Review 5.  Current Chemical, Biological, and Physiological Views in the Development of Successful Brain-Targeted Pharmaceutics.

Authors:  Magdalena Markowicz-Piasecka; Agata Markiewicz; Patrycja Darłak; Joanna Sikora; Santosh Kumar Adla; Sreelatha Bagina; Kristiina M Huttunen
Journal:  Neurotherapeutics       Date:  2022-04-07       Impact factor: 6.088

6.  Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity.

Authors:  Lei-lei Ma; Zhi-tao Wu; Le Wang; Xue-feng Zhang; Jing Wang; Chen Chen; Xuan Ni; Yun-fei Lin; Yi-yi Cao; Yang Luan; Guo-yu Pan
Journal:  Acta Pharmacol Sin       Date:  2016-01-25       Impact factor: 6.150

7.  Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Authors:  Maria Karlgren; Anna Vildhede; Ulf Norinder; Jacek R Wisniewski; Emi Kimoto; Yurong Lai; Ulf Haglund; Per Artursson
Journal:  J Med Chem       Date:  2012-05-15       Impact factor: 7.446

Review 8.  Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression.

Authors:  Takeo Nakanishi; Douglas D Ross
Journal:  Chin J Cancer       Date:  2011-11-18

9.  Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2.

Authors:  Joshua Bakhsheshian; Bih-Rong Wei; Ki-Eun Chang; Suneet Shukla; Suresh V Ambudkar; R Mark Simpson; Michael M Gottesman; Matthew D Hall
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-02       Impact factor: 11.205

Review 10.  The role of drug transporters in the kidney: lessons from tenofovir.

Authors:  Darren M Moss; Megan Neary; Andrew Owen
Journal:  Front Pharmacol       Date:  2014-11-11       Impact factor: 5.810
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