Literature DB >> 19251086

On the path to seeking novel radiosensitizers.

David Katz1, Emma Ito, Fei-Fei Liu.   

Abstract

Radiation therapy is a highly effective cancer treatment modality, and extensive investigations have been undertaken over the years to augment its efficacy in the clinic. This review summarizes the current understanding of the biologic bases underpinning many of the clinically used radiosensitizers. In addition, this review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.

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Year:  2009        PMID: 19251086     DOI: 10.1016/j.ijrobp.2008.12.002

Source DB:  PubMed          Journal:  Int J Radiat Oncol Biol Phys        ISSN: 0360-3016            Impact factor:   7.038


  17 in total

1.  Adapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkers.

Authors:  Qi Liu; Meng Wang; Ashley M Kern; Saman Khaled; Jing Han; Beow Y Yeap; Theodore S Hong; Jeff Settleman; Cyril H Benes; Kathryn D Held; Jason A Efstathiou; Henning Willers
Journal:  Mol Cancer Res       Date:  2015-02-09       Impact factor: 5.852

2.  The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.

Authors:  J Martinez-Useros; I Moreno; M J Fernandez-Aceñero; M Rodriguez-Remirez; A Borrero-Palacios; A Cebrian; T Gomez Del Pulgar; L Del Puerto-Nevado; W Li; A Puime-Otin; N Perez; M S Soengas; J Garcia-Foncillas
Journal:  BMC Cancer       Date:  2018-02-06       Impact factor: 4.430

3.  Radioprotection in normal tissue and delayed tumor growth by blockade of CD47 signaling.

Authors:  Justin B Maxhimer; David R Soto-Pantoja; Lisa A Ridnour; Hubert B Shih; William G Degraff; Maria Tsokos; David A Wink; Jeff S Isenberg; David D Roberts
Journal:  Sci Transl Med       Date:  2009-10-21       Impact factor: 17.956

4.  The radiosensitizer 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide induces DNA damage in EMT-6 mammary carcinoma cells.

Authors:  Joelle Haykal; Fady Geara; Makhluf J Haddadin; Colin A Smith; Hala Gali-Muhtasib
Journal:  Radiat Oncol       Date:  2009-07-14       Impact factor: 3.481

Review 5.  The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.

Authors:  Jessica L Geiger; Jennifer R Grandis; Julie E Bauman
Journal:  Oral Oncol       Date:  2015-12-28       Impact factor: 5.337

6.  Γ-Ionizing radiation-induced activation of the EGFR-p38/ERK-STAT3/CREB-1-EMT pathway promotes the migration/invasion of non-small cell lung cancer cells and is inhibited by podophyllotoxin acetate.

Authors:  Jeong Hyun Cho; Wan Gi Hong; Yu-Jin Jung; Jaeseok Lee; Eunah Lee; Sang-Gu Hwang; Hong-Duck Um; Jong Kuk Park
Journal:  Tumour Biol       Date:  2015-12-15

7.  γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers.

Authors:  Shibo Fu; Ying Yang; Tirtha K Das; Das Tirtha; Yun Yen; Bing-sen Zhou; Ming-Ming Zhou; Michael Ohlmeyer; Eric C Ko; Ross Cagan; Barry S Rosenstein; Shu-hsia Chen; Johnny Kao
Journal:  PLoS One       Date:  2012-06-29       Impact factor: 3.240

Review 8.  The molecular basis of chemoradiosensitivity in rectal cancer: implications for personalized therapies.

Authors:  Marian Grade; Hendrik A Wolff; Jochen Gaedcke; B Michael Ghadimi
Journal:  Langenbecks Arch Surg       Date:  2012-03-02       Impact factor: 3.445

9.  Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.

Authors:  Edwardine Labay; Elena V Efimova; Benjamin K Quarshie; Daniel W Golden; Ralph R Weichselbaum; Stephen J Kron
Journal:  Int J High Throughput Screen       Date:  2011-03

10.  Integrative radiogenomic profiling of squamous cell lung cancer.

Authors:  Mohamed E Abazeed; Drew J Adams; Kristen E Hurov; Pablo Tamayo; Chad J Creighton; Dmitriy Sonkin; Andrew O Giacomelli; Charles Du; Daniel F Fries; Kwok-Kin Wong; Jill P Mesirov; Jay S Loeffler; Stuart L Schreiber; Peter S Hammerman; Matthew Meyerson
Journal:  Cancer Res       Date:  2013-08-26       Impact factor: 12.701

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