| Literature DB >> 19250937 |
Daisuke Taura1, Michio Noguchi, Masakatsu Sone, Kiminori Hosoda, Eisaku Mori, Yohei Okada, Kazutoshi Takahashi, Koichiro Homma, Naofumi Oyamada, Megumi Inuzuka, Takuhiro Sonoyama, Ken Ebihara, Naohisa Tamura, Hiroshi Itoh, Hirofumi Suemori, Norio Nakatsuji, Hideyuki Okano, Shinya Yamanaka, Kazuwa Nakao.
Abstract
Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12 days of embryoid body formation and an additional 10 days of differentiation on Poly-l-ornithine and fibronectin- coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBPalpha, PPARgamma2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells.Entities:
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Year: 2009 PMID： 19250937 DOI： 10.1016/j.febslet.2009.02.031
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124