O Bakar1, Z Demircay, E Toker, S Cakir. 1. Department of Dermatology, Acibadem Kozyatagi Hospital, Istanbul, Turkey. ozgurtimurkaynak@hotmail.com
Abstract
BACKGROUND: Tetracycline derivatives provide moderate benefit in the treatment of ocular rosacea. Recently, azithromycin has been found to be an effective alternative in the treatment of cutaneous papulopustular rosacea. OBJECTIVE: We planned a study to evaluate the effects of azithromycin on ocular symptoms, signs and tear function tests of papulopustular rosacea patients. METHODS: An open-labelled study was performed in a population of 20 papulopustular rosacea patients. RESULTS: Eighteen subjects completed the trial. Significant improvement was seen in ocular symptoms, eyelid findings and conjunctival hyperaemia scores (P = 0.002, P < 0.0001, and P = 0.005, respectively). Therapeutic benefit was not observed in ocular surface staining scores. Baseline values of Schirmer test results were within normal limits. No significant side-effects were observed. Limitations The study population is limited to dermatology patients who had been referred to the ophthalmology clinic. CONCLUSION: Azithromycin may be a new promising therapeutic alternative in ocular rosacea.
BACKGROUND:Tetracycline derivatives provide moderate benefit in the treatment of ocular rosacea. Recently, azithromycin has been found to be an effective alternative in the treatment of cutaneous papulopustular rosacea. OBJECTIVE: We planned a study to evaluate the effects of azithromycin on ocular symptoms, signs and tear function tests of papulopustular rosaceapatients. METHODS: An open-labelled study was performed in a population of 20 papulopustular rosaceapatients. RESULTS: Eighteen subjects completed the trial. Significant improvement was seen in ocular symptoms, eyelid findings and conjunctival hyperaemia scores (P = 0.002, P < 0.0001, and P = 0.005, respectively). Therapeutic benefit was not observed in ocular surface staining scores. Baseline values of Schirmer test results were within normal limits. No significant side-effects were observed. Limitations The study population is limited to dermatology patients who had been referred to the ophthalmology clinic. CONCLUSION:Azithromycin may be a new promising therapeutic alternative in ocular rosacea.
Authors: Esther J van Zuuren; Zbys Fedorowicz; Ben Carter; Mireille M D van der Linden; Lyn Charland Journal: Cochrane Database Syst Rev Date: 2015-04-28