BACKGROUND: The effect of self-administered cocaine on extracellular dopamine (DA) levels has not been measured in humans. METHODS:Ten nondependent cocaine users underwentpositron emission tomography [11C]raclopride scans following intranasal self-administration of cocaine hydrochloride (1.0 mg/kg) and placebo powder. RESULTS: Compared with placebo, intranasal cocaine self-administration decreased [11C]raclopride binding values in the ventral limbic striatum and putamen. Individual differences in the magnitude of the [11C]raclopride response in the ventral striatum were predicted by lifetime histories of stimulant drug use. CONCLUSIONS: The results suggest that 1) intranasal cocaine self-administration increases synaptic DA levels in human striatum and 2) prior use of stimulant drugs on the street is associated with progressively greater cocaine-induced DA responses. These dopaminergic effects might influence susceptibility to drug-seeking behavior and the progression to substance abuse.
RCT Entities:
BACKGROUND: The effect of self-administered cocaine on extracellular dopamine (DA) levels has not been measured in humans. METHODS: Ten nondependent cocaine users underwent positron emission tomography [11C]raclopride scans following intranasal self-administration of cocaine hydrochloride (1.0 mg/kg) and placebo powder. RESULTS: Compared with placebo, intranasal cocaine self-administration decreased [11C]raclopride binding values in the ventral limbic striatum and putamen. Individual differences in the magnitude of the [11C]raclopride response in the ventral striatum were predicted by lifetime histories of stimulant drug use. CONCLUSIONS: The results suggest that 1) intranasal cocaine self-administration increases synaptic DA levels in human striatum and 2) prior use of stimulant drugs on the street is associated with progressively greater cocaine-induced DA responses. These dopaminergic effects might influence susceptibility to drug-seeking behavior and the progression to substance abuse.
Authors: Greg L West; Brandi Lee Drisdelle; Kyoko Konishi; Jonathan Jackson; Pierre Jolicoeur; Veronique D Bohbot Journal: Proc Biol Sci Date: 2015-06-07 Impact factor: 5.349
Authors: Aric Madayag; Kristen S Kau; Doug Lobner; John R Mantsch; Samantha Wisniewski; David A Baker Journal: J Neurosci Date: 2010-01-06 Impact factor: 6.167