Literature DB >> 19249674

EpCAM: another surface-to-nucleus missile.

Graham Carpenter1, Monica Red Brewer.   

Abstract

The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to EpCAM require regulated intramembrane proteolysis and a nucleocytoplasmic intracellular domain fragment.

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Year:  2009        PMID： 19249674     DOI： 10.1016/j.ccr.2009.02.005

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  25 in total

1.  Computational design of a CNT carrier for a high affinity bispecific anti-HER2 antibody based on trastuzumab and pertuzumab Fabs.

Authors:  Karim Salazar-Salinas; Carlos Kubli-Garfias; Jorge M Seminario
Journal:  J Mol Model       Date:  2012-11-10       Impact factor: 1.810

2.  The overexpression of epithelial cell adhesion molecule (EpCAM) in glioma.

Authors:  Xin Chen; Wei-Yuan Ma; Shang-Chen Xu; Yu Liang; Yi-Bing Fu; Bo Pang; Tao Xin; Hai-Tao Fan; Rui Zhang; Jian-Gang Luo; Wen-Qing Kang; Min Wang; Qi Pang
Journal:  J Neurooncol       Date:  2014-06-07       Impact factor: 4.130

3.  Cancer cells cut homophilic cell adhesion molecules and run.

Authors:  Sonya E L Craig; Susann M Brady-Kalnay
Journal:  Cancer Res       Date:  2010-11-17       Impact factor: 12.701

4.  Nuclear and cytoplasmic accumulation of Ep-ICD is frequently detected in human epithelial cancers.

Authors:  Ranju Ralhan; Helen C-H He; Anthony K-C So; Satyendra C Tripathi; Manish Kumar; Md Raghibul Hasan; Jatinder Kaur; Lawrence Kashat; Christina MacMillan; Shyam Singh Chauhan; Jeremy L Freeman; Paul G Walfish
Journal:  PLoS One       Date:  2010-11-30       Impact factor: 3.240

Review 5.  Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences.

Authors:  Olivier Gires; Nikolas H Stoecklein
Journal:  Cell Mol Life Sci       Date:  2014-08-08       Impact factor: 9.261

6.  Correlation between Claudin-18 expression and clinicopathological features and prognosis in patients with gastric cancer.

Authors:  Yufeng Lu; Tielong Wu; Yingyue Sheng; Yuanyuan Dai; Beilei Xia; Yuzheng Xue
Journal:  J Gastrointest Oncol       Date:  2020-12

7.  Monoclonal antibodies and Fc fragments for treating solid tumors.

Authors:  Andrea M Eisenbeis; Stefan J Grau
Journal:  Biologics       Date:  2012-01-05

8.  Activator protein 1 (AP-1) contributes to EpCAM-dependent breast cancer invasion.

Authors:  Narendra V Sankpal; John D Mayfield; Mike W Willman; Timothy P Fleming; William E Gillanders
Journal:  Breast Cancer Res       Date:  2011-12-01       Impact factor: 6.466

9.  Initial activation of EpCAM cleavage via cell-to-cell contact.

Authors:  Sabine Denzel; Dorothea Maetzel; Brigitte Mack; Carola Eggert; Gabriele Bärr; Olivier Gires
Journal:  BMC Cancer       Date:  2009-11-19       Impact factor: 4.430

10.  EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth.

Authors:  Agnieszka Martowicz; Johannes Rainer; Julien Lelong; Gilbert Spizzo; Guenther Gastl; Gerold Untergasser
Journal:  Mol Cancer       Date:  2013-06-10       Impact factor: 27.401
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