Literature DB >> 19249649

Stem cell therapy to reduce radiation-induced normal tissue damage.

Rob P Coppes1, Annemieke van der Goot, Isabelle M A Lombaert.   

Abstract

Normal tissue damage after radiotherapy is still a major problem in cancer treatment. Stem cell therapy may provide a means to reduce radiation-induced side effects and improve the quality of life of patients. This review discusses the current status in stem cell research with respect to their potential to reduce radiation toxicity. A number of different types of stem cells are being investigated for their potential to treat a variety of disorders. Their current status, localization, characterization, isolation, and potential in stem cell-based therapies are addressed. Although clinical adult stem cell research is still at an early stage, preclinical experiments show the potential these therapies may have. Based on the major advances made in this field, stem cell-based therapy has great potential to allow prevention or treatment of normal tissue damage after radiotherapy.

Entities:  

Mesh：

Year:  2009        PMID： 19249649     DOI： 10.1016/j.semradonc.2008.11.005

Source DB:  PubMed          Journal:  Semin Radiat Oncol        ISSN： 1053-4296            Impact factor:   5.934


  15 in total

1.  Bone marrow cells are a source of undifferentiated cells to prevent Sjögren's syndrome and to preserve salivary glands function in the non-obese diabetic mice.

Authors:  Saeed Khalili; Younan Liu; Yoshinori Sumita; Ola M Maria; David Blank; Sharon Key; Eva Mezey; Simon D Tran
Journal:  Int J Biochem Cell Biol       Date:  2010-08-21       Impact factor: 5.085

Review 2.  A systematic review of salivary gland hypofunction and xerostomia induced by cancer therapies: management strategies and economic impact.

Authors:  S B Jensen; A M L Pedersen; A Vissink; E Andersen; C G Brown; A N Davies; J Dutilh; J S Fulton; L Jankovic; N N F Lopes; A L S Mello; L V Muniz; C A Murdoch-Kinch; R G Nair; J J Napeñas; A Nogueira-Rodrigues; D Saunders; B Stirling; I von Bültzingslöwen; D S Weikel; L S Elting; F K L Spijkervet; M T Brennan
Journal:  Support Care Cancer       Date:  2010-03-25       Impact factor: 3.603

3.  Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation.

Authors:  Yoshinori Sumita; Younan Liu; Saeed Khalili; Ola M Maria; Dengsheng Xia; Sharon Key; Ana P Cotrim; Eva Mezey; Simon D Tran
Journal:  Int J Biochem Cell Biol       Date:  2010-10-07       Impact factor: 5.085

Review 4.  Strategies to improve radiotherapy with targeted drugs.

Authors:  Adrian C Begg; Fiona A Stewart; Conchita Vens
Journal:  Nat Rev Cancer       Date:  2011-04       Impact factor: 60.716

5.  Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.

Authors:  Diana Klein; Jennifer Steens; Alina Wiesemann; Florian Schulz; Farnusch Kaschani; Katharina Röck; Masahiro Yamaguchi; Florian Wirsdörfer; Markus Kaiser; Jens W Fischer; Martin Stuschke; Verena Jendrossek
Journal:  Antioxid Redox Signal       Date:  2016-11-14       Impact factor: 8.401

6.  A preclinical murine model for the early detection of radiation-induced brain injury using magnetic resonance imaging and behavioral tests for learning and memory: with applications for the evaluation of possible stem cell imaging agents and therapies.

Authors:  Ethel J Ngen; Lee Wang; Nishant Gandhi; Yoshinori Kato; Michael Armour; Wenlian Zhu; John Wong; Kathleen L Gabrielson; Dmitri Artemov
Journal:  J Neurooncol       Date:  2016-03-28       Impact factor: 4.130

Review 7.  Strategies for optimizing the response of cancer and normal tissues to radiation.

Authors:  Everett J Moding; Michael B Kastan; David G Kirsch
Journal:  Nat Rev Drug Discov       Date:  2013-07       Impact factor: 84.694

Review 8.  Stem cell therapies for the treatment of radiation-induced normal tissue side effects.

Authors:  Marc Benderitter; Fabio Caviggioli; Alain Chapel; Robert P Coppes; Chandan Guha; Marco Klinger; Olivier Malard; Fiona Stewart; Radia Tamarat; Peter van Luijk; Charles L Limoli
Journal:  Antioxid Redox Signal       Date:  2014-02-03       Impact factor: 8.401

9.  Isolation of mouse salivary gland stem cells.

Authors:  Sarah Pringle; Lalitha S Y Nanduri; Marianne van der Zwaag; Ronald van Os; Rob P Coppes
Journal:  J Vis Exp       Date:  2011-02-08       Impact factor: 1.355

10.  Feasibility of treating irradiated bone with intramedullary delivered autologous mesenchymal stem cells.

Authors:  Bérengère Phulpin; Gilles Dolivet; Pierre-Yves Marie; Sylvain Poussier; Sandrine Huger; Pierre Bravetti; Pierre Graff; Jean-Louis Merlin; Nguyen Tran
Journal:  J Biomed Biotechnol       Date:  2011-08-29
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